C
Clive N. Svendsen
Researcher at Cedars-Sinai Medical Center
Publications - 298
Citations - 24189
Clive N. Svendsen is an academic researcher from Cedars-Sinai Medical Center. The author has contributed to research in topics: Stem cell & Neural stem cell. The author has an hindex of 78, co-authored 283 publications receiving 21604 citations. Previous affiliations of Clive N. Svendsen include University of Wisconsin-Madison & University of California, Los Angeles.
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Journal ArticleDOI
Ocular changes in TgF344-AD rat model of Alzheimer's disease.
YuChun Tsai,Bin Lu,Alexander V. Ljubimov,Alexander V. Ljubimov,Sergey Girman,Fred N. Ross-Cisneros,Alfredo A. Sadun,Clive N. Svendsen,Clive N. Svendsen,Robert M. Cohen,Shaomei Wang +10 more
TL;DR: In this article, a transgenic rat model was used to investigate ocular abnormalities in early stages of Alzheimer's disease, and a novel AD transgenic mouse model was analyzed to further investigate the ocular abnormality.
Journal ArticleDOI
Survival, neuronal differentiation, and fiber outgrowth of propagated human neural precursor grafts in an animal model of Huntington's disease.
Richard J. E. Armstrong,Colin Watts,Clive N. Svendsen,Stephen B. Dunnett,Anne Elizabeth Rosser +4 more
TL;DR: This study supports the contention that propagated human neural precursors may ultimately be of use in therapeutic neural transplantation paradigms for diseases such as Huntington's disease.
Developmental alterations in Huntington's disease neural cells and pharmacological rescue in cells and mice
Ryan G. Lim,Lisa Salazar,D Wilton,Alvin R. King,Jennifer Stocksdale,Delaram Sharifabad,L Alice Lau,Beth Stevens,Jack C. Reidling,Sara T. Winokur,Malcolm Casale,Leslie M. Thompson,Mónica Pardo,A Gerardo García Díaz-Barriga,Marco Straccia,Phil Sanders,Jordi Alberch,Josep M. Canals,Julia A. Kaye,Mariah Dunlap,Lisa Jo,Hanna May,Elliot Mount,Cliff Anderson-Bergman,Kelly Haston,Steven Finkbeiner,Nicholas D. Allen,Paul J. Kemp,Ranjit Singh Atwal,Marta Biagioli,James F. Gusella,Marcy E. MacDonald,Sergey S Akimov,Nicolas Arbez,Jacqueline Stewart,Christopher A. Ross,Virginia B. Mattis,Colton M Tom,Loren Ornelas,Anais Sahabian,Lindsay Lenaeus,Berhan Mandefro,Dhruv Sareen,Clive N. Svendsen,Amanda J. Kedaigle,Theresa Anne Wasylenko,Ferah Yildirim,Christopher W. Ng,Pamela Milani,David E. Housman,Ernest Fraenkel +50 more
Journal ArticleDOI
Neurospheres modified to produce glial cell line-derived neurotrophic factor increase the survival of transplanted dopamine neurons
TL;DR: It is shown that rodent neural precursor cells isolated and expanded in culture as neurospheres (NS) can be genetically modified to express green fluorescent protein (GFP) or to release GDNF using lentiviral constructs and that sustained levels of neural precursor‐mediated transgene expression can be achieved following transplantation in the future.
Journal ArticleDOI
Long-term vision rescue by human neural progenitors in a rat model of photoreceptor degeneration.
Shaomei Wang,S.V. Girman,Bin Lu,N. Bischoff,Toby Holmes,R. L. Shearer,Lynda S. Wright,Clive N. Svendsen,David M. Gamm,Raymond D. Lund,Raymond D. Lund +10 more
TL;DR: Long-term rescue of function and associated morphologic substrates was seen, together with donor cell survival even in the xenograft paradigm, encouraging when exploring further the potential for the application of hNPC(ctx) in treating retinal disease.