C
Clive N. Svendsen
Researcher at Cedars-Sinai Medical Center
Publications - 298
Citations - 24189
Clive N. Svendsen is an academic researcher from Cedars-Sinai Medical Center. The author has contributed to research in topics: Stem cell & Neural stem cell. The author has an hindex of 78, co-authored 283 publications receiving 21604 citations. Previous affiliations of Clive N. Svendsen include University of Wisconsin-Madison & University of California, Los Angeles.
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Journal ArticleDOI
Faulty neuronal determination and cell polarization are reverted by modulating HD early phenotypes
Paola Conforti,Dario Besusso,Vittoria Dickinson Bocchi,Andrea Faedo,Elisabetta Cesana,Grazisa Rossetti,Valeria Ranzani,Clive N. Svendsen,Leslie M. Thompson,Mauro Toselli,Gerardo Biella,Massimiliano Pagani,Elena Cattaneo +12 more
TL;DR: It is reported that huntingtin mutation affects specific aspects of human neurodevelopment at the level of neuronal progenitor specification and its early commitment, leading to an abnormal cell organization and acquisition of mature neuronal identities in cerebral organoids.
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Delayed Disease Onset and Extended Survival in the SOD1G93A Rat Model of Amyotrophic Lateral Sclerosis after Suppression of Mutant SOD1 in the Motor Cortex
Gretchen M. Thomsen,Genevieve Gowing,Jessica Latter,Maximus Chen,Jean-Philippe Vit,Kevin Staggenborg,Pablo Avalos,Mor Alkaslasi,Laura Ferraiuolo,Shibi Likhite,Brian K. Kaspar,Clive N. Svendsen +11 more
TL;DR: It is shown that, in the SOD1G93A rat model of ALS, spinal motor neuron loss occurs presymptomatically and before degeneration of ventral root axons and denervation of NMJs, which suggests an early dysfunction and thus an important role of the upper motor neuron in this animal model ofALS and perhaps patients with the disease.
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Differentiating embryonic neural progenitor cells induce blood-brain barrier properties.
TL;DR: It is demonstrated that NPC–BMEC interactions are prevalent and for the first time demonstrates that NPC are capable of inducing BBB properties.
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Human iPSC-Derived Endothelial Cells and Microengineered Organ-Chip Enhance Neuronal Development
Samuel Sances,Ritchie Ho,Gad D. Vatine,Dylan West,Alex Laperle,Amanda Meyer,Marlesa Godoy,Paul S. Kay,Berhan Mandefro,Seigo Hatata,Chris Hinojosa,Norman Wen,Dhruv Sareen,Geraldine A. Hamilton,Clive N. Svendsen +14 more
TL;DR: The results show that the vascular system has specific maturation effects on spinal cord neural tissue, and the use of Organ-Chips can move stem cell models closer to an in vivo condition.
Journal ArticleDOI
Targeting ATM ameliorates mutant Huntingtin toxicity in cell and animal models of Huntington’s disease
Xiao-Hong Lu,Xiao-Hong Lu,Virginia B. Mattis,Nan Wang,Nan Wang,Ismael Al-Ramahi,Ismael Al-Ramahi,Nick van den Berg,Silvina A. Fratantoni,Henry J. Waldvogel,Erin R. Greiner,Erin R. Greiner,Alexander P. Osmand,Karla El-Zein,Karla El-Zein,Jingbo Xiao,Sipke Dijkstra,Remko de Pril,Harry V. Vinters,Richard L.M. Faull,Ethan Signer,Seung Kwak,Juan J. Marugan,Juan Botas,Juan Botas,David F. Fischer,Clive N. Svendsen,Ignacio Munoz-Sanjuan,X. William Yang,X. William Yang +29 more
TL;DR: This study provides converging genetic and pharmacological evidence that reduction of ATM signaling could ameliorate mHTT toxicity in cellular and animal models of HD, suggesting that ATM may be a useful therapeutic target for HD.