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Christopher L. Plaisier
Researcher at Arizona State University
Publications - 56
Citations - 5827
Christopher L. Plaisier is an academic researcher from Arizona State University. The author has contributed to research in topics: Gene & Biology. The author has an hindex of 23, co-authored 46 publications receiving 3840 citations. Previous affiliations of Christopher L. Plaisier include University of California, Los Angeles & University of Utah.
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Journal ArticleDOI
The Immune Landscape of Cancer
Vesteinn Thorsson,David L Gibbs,Scott D. Brown,Denise M. Wolf,Dante S. Bortone,Tai-Hsien Ou Yang,Eduard Porta-Pardo,Galen F. Gao,Christopher L. Plaisier,James A. Eddy,Elad Ziv,Aedín C. Culhane,Evan O. Paull,I K Ashok Sivakumar,Andrew J. Gentles,Raunaq Malhotra,Farshad Farshidfar,Antonio Colaprico,Joel S. Parker,Lisle E. Mose,Nam S Vo,Jianfang Liu,Yuexin Liu,Janet S. Rader,Varsha Dhankani,Sheila Reynolds,Reanne Bowlby,Andrea Califano,Andrew D. Cherniack,Dimitris Anastassiou,Davide Bedognetti,Arvind Rao,Ken Chen,Alexander Krasnitz,Hai Hu,Tathiane M. Malta,Houtan Noushmehr,Houtan Noushmehr,Chandra Sekhar Pedamallu,Susan Bullman,Akinyemi I. Ojesina,Andrew Lamb,Wanding Zhou,Hui Shen,Toni K. Choueiri,John N. Weinstein,Justin Guinney,Joel H. Saltz,Robert A. Holt,Charles E Rabkin,Alexander J. Lazar +50 more
TL;DR: An extensive immunogenomic analysis of more than 10,000 tumors comprising 33 diverse cancer types by utilizing data compiled by TCGA identifies six immune subtypes that encompass multiple cancer types and are hypothesized to define immune response patterns impacting prognosis.
Journal ArticleDOI
Integrating Genetic and Network Analysis to Characterize Genes Related to Mouse Weight
Anatole Ghazalpour,Sudheer Doss,Bin Zhang,Susanna Wang,Christopher L. Plaisier,Ruth Castellanos,Alec J. Brozell,Eric E. Schadt,Thomas A. Drake,Aldons J. Lusis,Steve Horvath +10 more
TL;DR: This work uses microarray and genetic marker data from an F2 mouse intercross to examine the large-scale organization of the gene co-expression network in liver, and annotates several gene modules in terms of 22 physiological traits.
Journal ArticleDOI
Targeted mutagenesis using zinc-finger nucleases in Arabidopsis
TL;DR: Data indicate that ZFNs can form the basis of a highly efficient method for targeted mutagenesis of plant genes and demonstrate efficient transmission of the ZFN-induced mutations.
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A systems genetics approach implicates USF1, FADS3, and other causal candidate genes for familial combined hyperlipidemia.
Christopher L. Plaisier,Steve Horvath,Adriana Huertas-Vazquez,Ivette Cruz-Bautista,Miguel F. Herrera,Teresa Tusié-Luna,Carlos A. Aguilar-Salinas,Päivi Pajukanta +7 more
TL;DR: It is hypothesized that a common SNP in the 3' untranslated region of the upstream transcription factor 1 (USF1), rs3737787, may affect lipid traits by influencing gene expression levels, and this possibility utilizing the Mexican population, which has a high predisposition to dyslipidemia.
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A miRNA-regulatory network explains how dysregulated miRNAs perturb oncogenic processes across diverse cancers
TL;DR: The utility of FIRM is demonstrated by inferring a cancer-miRNA regulatory network through the analysis of 2240 gene coexpression signatures from 46 cancers and a subset of 13 miRNAs that regulate oncogenic processes across diverse cancers are discovered.