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Colin Dinney
Researcher at University of Texas MD Anderson Cancer Center
Publications - 7
Citations - 808
Colin Dinney is an academic researcher from University of Texas MD Anderson Cancer Center. The author has contributed to research in topics: Bladder cancer & Caspase 10. The author has an hindex of 6, co-authored 7 publications receiving 431 citations.
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Journal ArticleDOI
A Consensus Molecular Classification of Muscle-invasive Bladder Cancer.
Aurélie Kamoun,Aurélien de Reyniès,Yves Allory,Yves Allory,Gottfrid Sjödahl,A. Gordon Robertson,Roland Seiler,Katherine A. Hoadley,Clarice S. Groeneveld,Clarice S. Groeneveld,Hikmat Al-Ahmadie,Woonyoung Choi,Mauro A. A. Castro,Jacqueline Fontugne,Jacqueline Fontugne,Pontus Eriksson,Qianxing Mo,Jordan Kardos,Alexandre R. Zlotta,Arndt Hartmann,Colin Dinney,Joaquim Bellmunt,Thomas Powles,Núria Malats,Keith S. Chan,William Y. Kim,David J. McConkey,Peter C. Black,Lars Dyrskjøt,Mattias Höglund,Seth P. Lerner,Francisco X. Real,François Radvanyi,Mattias Aine,Isabelle Bernard-Pierrot,Bogdan Czerniak,Ewan A. Gibb,Jaegil Kim,David J. Kwiatkowski,Thierry Lebret,Fredrik Liedberg,Arlene O. Siefker-Radtke,Nanor Sirab,Ann Taber,John N. Weinstein +44 more
TL;DR: In this paper, a consensus set of six molecular classes (luminal papillary (24%), luminal nonspecified (8), luminal unstable (15), stroma-rich (15%), basal/squamous (35%), and neuroendocrine-like (3%) was identified.
Journal ArticleDOI
Dysregulation of EMT Drives the Progression to Clinically Aggressive Sarcomatoid Bladder Cancer
Charles C. Guo,Tadeusz Majewski,Li Zhang,Hui Yao,Jolanta Bondaruk,Yan Wang,Shizhen Zhang,Ziqiao Wang,June Goo Lee,Sangkyou Lee,David Cogdell,Miao Zhang,Peng Wei,H. Barton Grossman,Ashish M. Kamat,Jonathan J. Duplisea,James E. Ferguson,He Huang,Vipulkumar Dadhania,Jianjun Gao,Colin Dinney,John N. Weinstein,Keith A. Baggerly,David J. McConkey,Bogdan Czerniak +24 more
TL;DR: Genomic analyses reveal that SARCs are driven by downregulation of homotypic adherence genes and dysregulation of the EMT network, and nearly half exhibit a heavily infiltrated immune phenotype, which has important implications for prognostication and the development of more effective therapies for this highly lethal variant of bladder cancer.
Posted ContentDOI
The consensus molecular classification of muscle-invasive bladder cancer
Aurélie Kamoun,Aurélien de Reyniès,Yves Allory,Gottfrid Sjödahl,A. Gordon Robertson,Roland Seiler,Katherine A. Hoadley,Hikmat Al-Ahmadie,Woonyoung Choi,Clarice S. Groeneveld,Mauro A. A. Castro,Jacqueline Fontugne,Pontus Eriksson,Qianxing Mo,Jordan Kardos,Alexandre R. Zlotta,Arndt Hartmann,Colin Dinney,Joaquim Bellmunt,Thomas Powles,Núria Malats,Keith S. Chan,William Y. Kim,David J. McConkey,Peter C. Black,Lars Dyrskjøt,Mattias Höglund,Seth P. Lerner,Francisco X. Real,François Radvanyi +29 more
TL;DR: A large international effort to reach a consensus on MIBC molecular subtypes is reported, which offers a robust framework that will enable testing and validating predictive biomarkers in future clinical trials.
Posted ContentDOI
Dysregulation of EMT Drives the Progression to Clinically Aggressive Sarcomatoid Bladder Cancer
Charles C. Guo,Tadeusz Majewski,Li Zhang,Hui Yao,Jolanta Bondaruk,Yan Wang,Shizhen Zhang,Ziqiao Wang,June Goo Lee,Sangkyou Lee,David Cogdell,Miao Zhang,Peng Wei,H. Barton Grossman,Ashish M. Kamat,Jonathan J. Duplisea,James E. Ferguson,He Huang,Vipulkumar Dadhania,Colin Dinney,John N. Weinstein,Keith A. Baggerly,David J. McConkey,Bogdan Czerniak +23 more
TL;DR: Genomic analyses revealed that SARCs are driven by downregulation of homotypic adherence genes and dysregulation of cell cycle and EMT networks, and nearly half exhibited a heavily infiltrated immune phenotype.
Journal ArticleDOI
Use of monitoring levels of soluble forms of cytokeratin 18 in the urine of patients with superficial bladder cancer following intravesical Ad-IFNα/Syn3 treatment in a phase l study
TL;DR: The return of both M30 and M65 levels in the urine to normal levels within 5 days or more after treatment was strongly associated with obtaining a CR and in the future may prove valuable in predicting clinical outcome.