I
Isabelle Bernard-Pierrot
Researcher at PSL Research University
Publications - 59
Citations - 2805
Isabelle Bernard-Pierrot is an academic researcher from PSL Research University. The author has contributed to research in topics: Bladder cancer & Gene. The author has an hindex of 22, co-authored 52 publications receiving 2095 citations. Previous affiliations of Isabelle Bernard-Pierrot include Curie Institute & Centre national de la recherche scientifique.
Papers
More filters
Journal ArticleDOI
A Consensus Molecular Classification of Muscle-invasive Bladder Cancer.
Aurélie Kamoun,Aurélien de Reyniès,Yves Allory,Yves Allory,Gottfrid Sjödahl,A. Gordon Robertson,Roland Seiler,Katherine A. Hoadley,Clarice S. Groeneveld,Clarice S. Groeneveld,Hikmat Al-Ahmadie,Woonyoung Choi,Mauro A. A. Castro,Jacqueline Fontugne,Jacqueline Fontugne,Pontus Eriksson,Qianxing Mo,Jordan Kardos,Alexandre R. Zlotta,Arndt Hartmann,Colin Dinney,Joaquim Bellmunt,Thomas Powles,Núria Malats,Keith S. Chan,William Y. Kim,David J. McConkey,Peter C. Black,Lars Dyrskjøt,Mattias Höglund,Seth P. Lerner,Francisco X. Real,François Radvanyi,Mattias Aine,Isabelle Bernard-Pierrot,Bogdan Czerniak,Ewan A. Gibb,Jaegil Kim,David J. Kwiatkowski,Thierry Lebret,Fredrik Liedberg,Arlene O. Siefker-Radtke,Nanor Sirab,Ann Taber,John N. Weinstein +44 more
TL;DR: In this paper, a consensus set of six molecular classes (luminal papillary (24%), luminal nonspecified (8), luminal unstable (15), stroma-rich (15%), basal/squamous (35%), and neuroendocrine-like (3%) was identified.
Journal ArticleDOI
EGFR as a potential therapeutic target for a subset of muscle-invasive bladder cancers presenting a basal-like phenotype
Sandra Rebouissou,Isabelle Bernard-Pierrot,Aurélien de Reyniès,May-Linda Lepage,Clémentine Krucker,Elodie Chapeaublanc,Aurélie Hérault,Aurélie Kamoun,Aurélie Caillault,Eric Letouzé,Nabila Elarouci,Yann Neuzillet,Yves Denoux,Vincent Molinié,Dimitri Vordos,Agnès Laplanche,Pascale Maillé,Pascale Soyeux,Pascale Soyeux,Karina Ofualuka,Karina Ofualuka,Fabien Reyal,Anne Biton,Mathilde Sibony,Xavier Paoletti,Jennifer Southgate,Simone Benhamou,Simone Benhamou,Thierry Lebret,Yves Allory,François Radvanyi +30 more
TL;DR: Preclinical proof of concept that anti-EGFR therapy can be used to target a subset of particularly aggressive MIBC tumors expressing basal cell markers is provided and diagnostic tools for identifying these tumors are provided.
Journal ArticleDOI
Regional copy number–independent deregulation of transcription in cancer
Nicolas Stransky,Céline Vallot,Fabien Reyal,Isabelle Bernard-Pierrot,Sixtina Gil Diez de Medina,Sixtina Gil Diez de Medina,Rick Segraves,Yann De Rycke,Paul Elvin,Andrew Cassidy,Carolyn Spraggon,Alexander Graham,Jennifer Southgate,Bernard Asselain,Yves Allory,Claude C. Abbou,Donna G. Albertson,Jean Paul Thiery,Jean Paul Thiery,Jean Paul Thiery,Dominique K. Chopin,Daniel Pinkel,François Radvanyi +22 more
TL;DR: In this article, a search for regions susceptible to epigenetic suppression of gene expression can also extend to a whole region; this is known as long-range epigenetic silencing.
Journal ArticleDOI
Independent Component Analysis Uncovers the Landscape of the Bladder Tumor Transcriptome and Reveals Insights into Luminal and Basal Subtypes
Anne Biton,Isabelle Bernard-Pierrot,Yinjun Lou,Clémentine Krucker,Elodie Chapeaublanc,Carlota Rubio-Perez,Nuria Lopez-Bigas,Nuria Lopez-Bigas,Aurélie Kamoun,Yann Neuzillet,Pierre Gestraud,Pierre Gestraud,Pierre Gestraud,Luca Grieco,Luca Grieco,Luca Grieco,Sandra Rebouissou,Aurélien de Reyniès,Simone Benhamou,Simone Benhamou,Thierry Lebret,Jennifer Southgate,Emmanuel Barillot,Emmanuel Barillot,Emmanuel Barillot,Yves Allory,Yves Allory,Andrei Zinovyev,Andrei Zinovyev,Andrei Zinovyev,François Radvanyi +30 more
TL;DR: This work applied independent component analysis (ICA) to bladder cancer transcriptome data sets and interpreted the components using gene enrichment analysis and tumor-associated molecular, clinicopathological, and processing information, and identified components associated with biological processes of tumor cells or the tumor microenvironment.
Journal ArticleDOI
Integrative modelling of the influence of MAPK network on cancer cell fate decision.
Luca Grieco,Laurence Calzone,Isabelle Bernard-Pierrot,François Radvanyi,Brigitte Kahn-Perlès,Denis Thieffry +5 more
TL;DR: A comprehensive and generic reaction map for the MAPK signalling network is built, using CellDesigner software, and tentative proliferative or anti-proliferative mechanisms can be connected with established bladder cancer deregulations, namely Epidermal Growth Factor Receptor over-expression and Fibroblast Growth factor Receptor 3 activating mutations.