K
Keith S. Chan
Researcher at Cedars-Sinai Medical Center
Publications - 11
Citations - 892
Keith S. Chan is an academic researcher from Cedars-Sinai Medical Center. The author has contributed to research in topics: Bladder cancer & Cancer. The author has an hindex of 5, co-authored 11 publications receiving 393 citations. Previous affiliations of Keith S. Chan include Baylor University & Baylor College of Medicine.
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Journal ArticleDOI
A Consensus Molecular Classification of Muscle-invasive Bladder Cancer.
Aurélie Kamoun,Aurélien de Reyniès,Yves Allory,Yves Allory,Gottfrid Sjödahl,A. Gordon Robertson,Roland Seiler,Katherine A. Hoadley,Clarice S. Groeneveld,Clarice S. Groeneveld,Hikmat Al-Ahmadie,Woonyoung Choi,Mauro A. A. Castro,Jacqueline Fontugne,Jacqueline Fontugne,Pontus Eriksson,Qianxing Mo,Jordan Kardos,Alexandre R. Zlotta,Arndt Hartmann,Colin Dinney,Joaquim Bellmunt,Thomas Powles,Núria Malats,Keith S. Chan,William Y. Kim,David J. McConkey,Peter C. Black,Lars Dyrskjøt,Mattias Höglund,Seth P. Lerner,Francisco X. Real,François Radvanyi,Mattias Aine,Isabelle Bernard-Pierrot,Bogdan Czerniak,Ewan A. Gibb,Jaegil Kim,David J. Kwiatkowski,Thierry Lebret,Fredrik Liedberg,Arlene O. Siefker-Radtke,Nanor Sirab,Ann Taber,John N. Weinstein +44 more
TL;DR: In this paper, a consensus set of six molecular classes (luminal papillary (24%), luminal nonspecified (8), luminal unstable (15), stroma-rich (15%), basal/squamous (35%), and neuroendocrine-like (3%) was identified.
Journal ArticleDOI
Tipping the immunostimulatory and inhibitory DAMP balance to harness immunogenic cell death.
Kazukuni Hayashi,Kazukuni Hayashi,Fotis Nikolos,Y. C. Lee,Antrix Jain,Efrosini Tsouko,H. Gao,A. Kasabyan,Hon-Chiu Eastwood Leung,A. Osipov,Sung Yun Jung,Antonina V. Kurtova,Keith S. Chan +12 more
TL;DR: It is postulated that an intricate balance between immunostimulatory and inhibitory DAMPs could determine the outcome of drug-induced ICD and pose COX-2/prostaglandin E2 blockade as a strategy to harness ICD.
Posted ContentDOI
The consensus molecular classification of muscle-invasive bladder cancer
Aurélie Kamoun,Aurélien de Reyniès,Yves Allory,Gottfrid Sjödahl,A. Gordon Robertson,Roland Seiler,Katherine A. Hoadley,Hikmat Al-Ahmadie,Woonyoung Choi,Clarice S. Groeneveld,Mauro A. A. Castro,Jacqueline Fontugne,Pontus Eriksson,Qianxing Mo,Jordan Kardos,Alexandre R. Zlotta,Arndt Hartmann,Colin Dinney,Joaquim Bellmunt,Thomas Powles,Núria Malats,Keith S. Chan,William Y. Kim,David J. McConkey,Peter C. Black,Lars Dyrskjøt,Mattias Höglund,Seth P. Lerner,Francisco X. Real,François Radvanyi +29 more
TL;DR: A large international effort to reach a consensus on MIBC molecular subtypes is reported, which offers a robust framework that will enable testing and validating predictive biomarkers in future clinical trials.
Journal ArticleDOI
An N-Cadherin 2 expressing epithelial cell subpopulation predicts response to surgery, chemotherapy and immunotherapy in bladder cancer
Kenneth Gouin,Nathan Ing,Jasmine T. Plummer,Charles J. Rosser,Bassem Ben Cheikh,Catherine Oh,Stephanie S. Chen,Keith S. Chan,Hideki Furuya,Warren G. Tourtellotte,Simon R.V. Knott,Dan Theodorescu +11 more
TL;DR: In this article, the authors combine single nuclei RNA sequencing with spatial transcriptomics and single-cell resolution spatial proteomic analysis of human bladder cancer to identify an epithelial subpopulation with therapeutic response prediction ability.
Journal ArticleDOI
Integrative multi-omics analysis of muscle-invasive bladder cancer identifies prognostic biomarkers for frontline chemotherapy and immunotherapy.
TL;DR: An integrative clustering analysis of 388 MIBC samples with multi-omics data identifies basal and luminal/differentiated integrative subtypes and derived a 42 gene panel for classification of MIBC and identifies genes associated with response to PD-L1 blockade immunotherapy, suggesting potential clinical use of these genes’ expression signature.