K
Kenichi Yoshida
Researcher at Wellcome Trust Sanger Institute
Publications - 5
Citations - 341
Kenichi Yoshida is an academic researcher from Wellcome Trust Sanger Institute. The author has contributed to research in topics: Population & Haematopoiesis. The author has an hindex of 3, co-authored 5 publications receiving 154 citations.
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Journal ArticleDOI
Tobacco smoking and somatic mutations in human bronchial epithelium
Kenichi Yoshida,Kate H.C. Gowers,Henry Lee-Six,Deepak P. Chandrasekharan,Tim H. H. Coorens,Elizabeth F. Maughan,Kathryn Beal,Andrew Menzies,Fraser R. Millar,Elizabeth Anderson,Sarah E. Clarke,Adam Pennycuick,Ricky Thakrar,Ricky Thakrar,Colin R. Butler,Colin R. Butler,Nobuyuki Kakiuchi,Tomonori Hirano,Robert E. Hynds,Michael R. Stratton,Inigo Martincorena,Sam M. Janes,Sam M. Janes,Peter J. Campbell,Peter J. Campbell +24 more
TL;DR: W Whole-genome sequencing of normal bronchial epithelium from 16 individuals shows that tobacco smoking increases genomic heterogeneity, mutational burden and driver mutations, whereas stopping smoking promotes replenishment of the epithelia with near-normal cells.
Journal ArticleDOI
Lineage tracing of human development through somatic mutations
Michael Spencer Chapman,Michael Spencer Chapman,Michael Spencer Chapman,Anna Maria Ranzoni,Anna Maria Ranzoni,Anna Maria Ranzoni,Brynelle Myers,Brynelle Myers,Brynelle Myers,Nicholas Williams,Tim H. H. Coorens,Emily Mitchell,Emily Mitchell,Emily Mitchell,Tim Butler,Kevin J. Dawson,Yvette Hooks,Luiza Moore,Luiza Moore,Jyoti Nangalia,Jyoti Nangalia,Jyoti Nangalia,Philip S. Robinson,Philip S. Robinson,Kenichi Yoshida,Elizabeth Hook,Peter J. Campbell,Peter J. Campbell,Ana Cvejic,Ana Cvejic,Ana Cvejic +30 more
TL;DR: In this paper, the ontogeny of the human haematopoietic system during fetal development has been characterized mainly through careful microscopic observations and deep targeted sequencing of tissues of known embryonic origin.
Iconographies supplémentaires de l'article : Phosphatase and tensin homolog ( PTEN ) mutation can cause activated phosphatidylinositol 3-kinase ? syndrome–like immunodeficiency
Yuki Tsujita,Kanako Mitsui-Sekinaka,Kohsuke Imai,Tzu-Wen Yeh,Noriko Mitsuiki,Takaki Asano,Hidenori Ohnishi,Zenichiro Kato,Yujin Sekinaka,Kiyotaka Zaha,Tamaki Kato,Tsubasa Okano,Takehiro Takashima,Kaoru Kobayashi,Mitsuaki Kimura,Tomoaki Kunitsu,Yoshihiro Maruo,Hirokazu Kanegane,Masatoshi Takagi,Kenichi Yoshida,Yusuke Okuno,Hideki Muramatsu,Yuichi Shiraishi,Kenichi Chiba,Hiroko Tanaka,Satoru Miyano,Seiji Kojima,Seishi Ogawa,Osamu Ohara,Satoshi Okada,Masao Kobayashi,Tomohiro Morio,Shigeaki Nonoyama +32 more
TL;DR: PTEN loss-of-function mutations can cause APDS-like immunodeficiency because of aberrant PI3K pathway activation in lymphocytes.
Proceedings ArticleDOI
Tobacco exposure and somatic mutations in normal human bronchial epithelium
Kenichi Yoshida,Kate H.C. Gowers,Henry Lee-Six,Deepak P. Chandrasekharan,Tim H. H. Coorens,Elizabeth F. Maughan,Kathryn Beal,Andrew Menzies,Fraser R. Millar,Elizabeth M. Anderson,Sarah E. Clarke,Adam Pennycuick,Ricky Thakrar,Colin R. Butler,Nobuyuki Kakiuchi,Tomonori Hirano,Robert E. Hynds,Michael R. Stratton,Inigo Martincorena,Sam M. Janes,Peter J. Campbell +20 more
TL;DR: In this paper, the authors sequenced whole genomes of 632 colonies derived from single bronchial epithelial cells across 16 subjects and found that tobacco smoking was the major influence on mutation burden, adding 1000-10,000+ mutations/cell.
marrow failure in Japanese Fanconi anemia patients Variant ALDH2 is associated with accelerated progression of bone
Miharu Yabe,Satoru Miyano,Jun Nakamura,Seiji Kojima,Seishi Ogawa,Keitaro Matsuo,Minoru Takata,Asuka Hira,Hiromasa Yabe,Kenichi Yoshida,Yusuke Okuno,Yuichi Shiraishi,Kenichi Chiba +12 more
TL;DR: The objective of this study was to establish an experimental procedure to establish whether the presence of EMTs in the blood of mice indicates an elevated risk of central giant cell granuloma.