Constanze Bonifer

TL;DR: It is concluded that LTR derepression is involved in the pathogenesis of human lymphomas, a finding that might have diagnostic, prognostic and therapeutic implications.

TL;DR: A 21.5-kb DNA fragment carrying the entire chicken lysozyme gene locus was introduced into the germ line of mice as discussed by the authors, which contained the transcribed region plus 11.5 kb 5'-flanking and 5.5' and 3' attachment elements (A-elements) defining the borders of the DNase I sensitive chromatin domain.

TL;DR: This study introduces a novel algorithm, Wellington, which considers the imbalance in the DNA strand-specific alignment information of DNase-seq data surrounding protein–DNA interactions that allows accurate prediction of occupied TF binding sites to efficiently identify DNA footprints.

TL;DR: The results indicate that COX-2 is expressed predominantly by interstitial macrophages within human sporadic colorectal adenomas, and suggests COx-2-mediated paracrine signaling between the macrophage and epithelial cells withinAdenomas in man.

TL;DR: This study generated global gene expression, chromatin accessibility, histone modification, and transcription factor binding data from purified embryonic stem cell-derived cells representing six sequential stages of hematopoietic specification and differentiation to reveal the nature of regulatory elements driving differential gene expression and inform how transcription factorbinding impacts on promoter activity.