A
Arash Yavari
Researcher at University of Oxford
Publications - 37
Citations - 1153
Arash Yavari is an academic researcher from University of Oxford. The author has contributed to research in topics: AMPK & AMP-activated protein kinase. The author has an hindex of 15, co-authored 32 publications receiving 895 citations. Previous affiliations of Arash Yavari include Wellcome Trust Centre for Human Genetics & University of East Anglia.
Papers
More filters
Journal ArticleDOI
Fumarate is cardioprotective via activation of the Nrf2 antioxidant pathway.
Houman Ashrafian,Gabor Czibik,Mohamed Bellahcene,Dunja Aksentijevic,Anthony C. Smith,Sarah J. Mitchell,Sarah J. Mitchell,Michael S. Dodd,Jennifer A. Kirwan,Jonathan J. Byrne,Christian Ludwig,Henrik Isackson,Arash Yavari,Nicolaj B. Støttrup,Hussain Contractor,Thomas J. Cahill,Natasha Sahgal,Daniel R. Ball,Rune Isak Dupont Birkler,Iain P. Hargreaves,Daniel A. Tennant,John M. Land,Craig A. Lygate,Mogens Johannsen,Rajesh K. Kharbanda,Stefan Neubauer,Charles Redwood,Rafael de Cabo,Ismayil Ahmet,Mark I. Talan,Ulrich L. Günther,Alan J. Robinson,Mark R. Viant,Patrick J. Pollard,Damian J. Tyler,Hugh Watkins +35 more
TL;DR: It is proposed that clinically established fumarate derivatives activate the Nrf2 pathway and are readily testable cytoprotective agents.
Journal ArticleDOI
Hydroxychloroquine reduces heart rate by modulating the hyperpolarization-activated current If: Novel electrophysiological insights and therapeutic potential.
Rebecca A. Capel,Neil Herring,Manish Kalla,Arash Yavari,Gary R. Mirams,Gillian Douglas,Gil Bub,Keith M. Channon,David J. Paterson,Derek A. Terrar,Rebecca-Ann B. Burton +10 more
TL;DR: It is shown that HCQ acts as a bradycardic agent in SAN cells, in atrial preparations, and in vivo, without significantly reducing mean arterial blood pressure.
Journal ArticleDOI
Effect of Selective Heart Rate Slowing in Heart Failure With Preserved Ejection Fraction
Nikhil Pal,Nadiya Sivaswamy,Masliza Mahmod,Arash Yavari,Amelia Rudd,Satnam Singh,Dana Dawson,Jane M. Francis,Jeremy S Dwight,Hugh Watkins,Stefan Neubauer,Michael P. Frenneaux,Houman Ashrafian +12 more
TL;DR: The observations bring into question the value of heart rate reduction with ivabradine for improving symptoms in a HFpEF population characterized by exercise limitation.
Journal ArticleDOI
Chronic Activation of γ2 AMPK Induces Obesity and Reduces β Cell Function.
Arash Yavari,Arash Yavari,Claire J. Stocker,Sahar Ghaffari,Sahar Ghaffari,Edward T. Wargent,Violetta Steeples,Violetta Steeples,Gabor Czibik,Gabor Czibik,Katalin Pinter,Katalin Pinter,Mohamed Bellahcene,Mohamed Bellahcene,Angela Woods,Pablo B. Martínez de Morentin,Céline Cansell,Brian Y.H. Lam,André Chuster,Kasparas Petkevicius,Marie Sophie Nguyen-Tu,Aida Martinez-Sanchez,Timothy J. Pullen,Peter L. Oliver,A Stockenhuber,A Stockenhuber,Chinh Duc Nguyen,Chinh Duc Nguyen,Merzaka Lazdam,Jacqueline F. O’Dowd,Parvathy E. Harikumar,Mónika Tóth,Craig Beall,Theodosios Kyriakou,Theodosios Kyriakou,Julia Parnis,Julia Parnis,Dhruv Sarma,Dhruv Sarma,George D. Katritsis,George D. Katritsis,Diana D.J. Wortmann,Diana D.J. Wortmann,Andrew R. Harper,Andrew R. Harper,Laurence A. Brown,Robin Willows,Silvia Gandra,Victor Poncio,Márcio Jansen de Oliveira Figueiredo,Nathan Qi,Stuart N. Peirson,Rory J. McCrimmon,Balázs Gereben,Laszlo Tretter,Csaba Fekete,Csaba Fekete,Charles Redwood,Charles Redwood,Giles S.H. Yeo,Lora K. Heisler,Guy A. Rutter,Mark A. Smith,Dominic J. Withers,David Carling,Eduardo Back Sternick,Jonathan R.S. Arch,Michael A. Cawthorne,Hugh Watkins,Hugh Watkins,Houman Ashrafian +70 more
TL;DR: It is observed that mice with chronic AMPK activation, resulting from mutation of the AMPK γ2 subunit, exhibit ghrelin signaling-dependent hyperphagia, obesity, and impaired pancreatic islet insulin secretion.
Journal ArticleDOI
AMP-Activated Protein Kinase Phosphorylates Cardiac Troponin I and Alters Contractility of Murine Ventricular Myocytes
S M Oliveira,Yin Hua Zhang,Raquel Sancho Solis,Henrik Isackson,Mohamed Bellahcene,Arash Yavari,Katalin Pinter,Joanna K. Davies,Ying Ge,Houman Ashrafian,Jeffery W. Walker,David Carling,Hugh Watkins,Barbara Casadei,Charles Redwood +14 more
TL;DR: A yeast 2-hybrid screen of a human heart cDNA library using the N-terminal 273 residues of γ2 as bait identified cardiac troponin I (cTnI) as a putative interactor as discussed by the authors.