M
Mogens Johannsen
Researcher at Aarhus University
Publications - 106
Citations - 3660
Mogens Johannsen is an academic researcher from Aarhus University. The author has contributed to research in topics: Catalysis & Enantioselective synthesis. The author has an hindex of 33, co-authored 98 publications receiving 3096 citations. Previous affiliations of Mogens Johannsen include University of Virginia & Aarhus University Hospital.
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Journal ArticleDOI
Fumarate is cardioprotective via activation of the Nrf2 antioxidant pathway.
Houman Ashrafian,Gabor Czibik,Mohamed Bellahcene,Dunja Aksentijevic,Anthony C. Smith,Sarah J. Mitchell,Sarah J. Mitchell,Michael S. Dodd,Jennifer A. Kirwan,Jonathan J. Byrne,Christian Ludwig,Henrik Isackson,Arash Yavari,Nicolaj B. Støttrup,Hussain Contractor,Thomas J. Cahill,Natasha Sahgal,Daniel R. Ball,Rune Isak Dupont Birkler,Iain P. Hargreaves,Daniel A. Tennant,John M. Land,Craig A. Lygate,Mogens Johannsen,Rajesh K. Kharbanda,Stefan Neubauer,Charles Redwood,Rafael de Cabo,Ismayil Ahmet,Mark I. Talan,Ulrich L. Günther,Alan J. Robinson,Mark R. Viant,Patrick J. Pollard,Damian J. Tyler,Hugh Watkins +35 more
TL;DR: It is proposed that clinically established fumarate derivatives activate the Nrf2 pathway and are readily testable cytoprotective agents.
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IFI16 is required for DNA sensing in human macrophages by promoting production and function of cGAMP
Kasper L Jønsson,Anders Laustsen,Christian Krapp,Christian Krapp,Kristian Alsbjerg Skipper,Karthiga Thavachelvam,Dominik Hotter,Johanne H Egedal,Mads Kjolby,Mads Kjolby,Pejman Mohammadi,Thaneas Prabakaran,Lambert K. Sørensen,Chenglong Sun,Søren B. Jensen,Christian K. Holm,Robert Jan Lebbink,Mogens Johannsen,Mette Nyegaard,Jacob Giehm Mikkelsen,Frank Kirchhoff,Søren R. Paludan,Martin R. Jakobsen +22 more
TL;DR: The results suggest that IFI16 is essential for efficient sensing and signalling upon DNA challenge in macrophages to promote interferons and antiviral responses.
Journal ArticleDOI
Catalytic Asymmetric Addition Reactions of Carbonyls. A Common Catalytic Approach
Journal ArticleDOI
cGAS is activated by DNA in a length-dependent manner.
Stefanie Luecke,Andreas Holleufer,Maria H Christensen,Kasper L Jønsson,Gerardo A Boni,Lambert K. Sørensen,Mogens Johannsen,Martin R. Jakobsen,Rune Hartmann,Søren R. Paludan +9 more
TL;DR: In vitro studies reveal that long DNA activates recombinant human cGAS more efficiently than short DNA, showing that length‐dependent DNA recognition is an intrinsic property of cGas independent of accessory proteins.
Journal ArticleDOI
New air-stable planar chiral ferrocenyl monophosphine ligands: Suzuki cross-coupling of aryl chlorides and bromides.
Jakob F. Jensen,Mogens Johannsen +1 more
TL;DR: A novel class of planar chiral electron-rich monophosphine ligands has been developed that allows a short and efficient synthesis of an array of aryl-ferrocenyl derivatives carrying the donating bis(dicyclohexyl)phosphino moiety.