W
Welkin H. Pope
Researcher at University of Pittsburgh
Publications - 68
Citations - 2522
Welkin H. Pope is an academic researcher from University of Pittsburgh. The author has contributed to research in topics: Genome & Mycobacteriophages. The author has an hindex of 21, co-authored 66 publications receiving 1969 citations. Previous affiliations of Welkin H. Pope include Woods Hole Oceanographic Institution & Massachusetts Institute of Technology.
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Journal ArticleDOI
A Broadly Implementable Research Course in Phage Discovery and Genomics for First-Year Undergraduate Students
Tuajuanda C. Jordan,Sandra H. Burnett,Susan Carson,Steven M. Caruso,Kari Clase,Randall J. DeJong,John J. Dennehy,Dee R. Denver,David Dunbar,Sarah C. R. Elgin,Ann M. Findley,Chris R. Gissendanner,Urszula Golebiewska,Nancy Guild,Grant A. Hartzog,Wendy H. Grillo,Gail P. Hollowell,Lee E. Hughes,Allison Johnson,Rodney A. King,Lynn O. Lewis,Wei Li,Frank Rosenzweig,Michael R. Rubin,Margaret S. Saha,James Sandoz,Christopher D. Shaffer,Barbara J. Taylor,Larissa K. Temple,Edwin Vazquez,Vassie C. Ware,Lucia P. Barker,Kevin W. Bradley,Deborah Jacobs-Sera,Welkin H. Pope,Daniel A. Russell,Steven G. Cresawn,David Lopatto,Cheryl Bailey,Graham F. Hatfull +39 more
TL;DR: A general model in which faculty and teaching assistants from diverse academic institutions are trained to teach a research course for first-year undergraduate students focused on bacteriophage discovery and genomics is developed, showing that this alliance-sourced model not only substantially advances the field of phage genomics but also stimulates students’ interest in science, positively influences academic achievement, and enhances persistence inScience, technology, engineering, and mathematics (STEM) disciplines.
Journal ArticleDOI
Comparative genomic analysis of 60 Mycobacteriophage genomes: genome clustering, gene acquisition, and gene size.
Graham F. Hatfull,Deborah Jacobs-Sera,Jeffrey G. Lawrence,Welkin H. Pope,Daniel A. Russell,Ching-Chung Ko,Rebecca J. Weber,Manisha C. Patel,Katherine L. Germane,Robert H. Edgar,Natasha N. Hoyte,Charles A. Bowman,Anthony T. Tantoco,Elizabeth C. Paladin,Marlana S. Myers,Alexis L. Smith,Molly S. Grace,Thuy T. Pham,Matthew B. O'Brien,Amy M. Vogelsberger,Andrew J. Hryckowian,Jessica L. Wynalek,Helen Donis-Keller,Matt W. Bogel,Craig L. Peebles,Steven G. Cresawn,Roger W. Hendrix +26 more
TL;DR: Expansion of a collection of sequenced phage genomes to a total of 60-all infecting a common bacterial host-provides further insight into their diversity and evolution.
Journal ArticleDOI
Whole Genome Comparison of a Large Collection of Mycobacteriophages Reveals a Continuum of Phage Genetic Diversity
Welkin H. Pope,Charles A. Bowman,Daniel A. Russell,Deborah Jacobs-Sera,David J. Asai,Steven G. Cresawn,William R. Jacobs,Roger W. Hendrix,Jeffrey G. Lawrence,Graham F. Hatfull +9 more
TL;DR: To understand the population structure of phages infecting a single host strain, 627 phages of Mycobacterium smegmatis were isolated, sequenced, and compared to reveal a continuum of genetic diversity, albeit with uneven representation of different phages.
Journal ArticleDOI
Prophage-mediated defence against viral attack and viral counter-defence.
Rebekah M. Dedrick,Deborah Jacobs-Sera,Carlos A. Guerrero Bustamante,Rebecca A. Garlena,Travis N. Mavrich,Welkin H. Pope,Juan C. Cervantes Reyes,Daniel A. Russell,Tamarah L. Adair,Richard M Alvey,J. Alfred Bonilla,Jerald S. Bricker,Bryony R. Brown,Deanna Byrnes,Steven G. Cresawn,William B. Davis,Leon A. Dickson,Nicholas P. Edgington,Ann M. Findley,Urszula Golebiewska,Julianne H. Grose,Cory F. Hayes,Lee E. Hughes,Keith W. Hutchison,Sharon Isern,Allison Johnson,Margaret A. Kenna,Karen K. Klyczek,Catherine M. Mageeney,Scott F. Michael,Sally D. Molloy,Matthew T. Montgomery,James Neitzel,Shallee T. Page,Marie C. Pizzorno,Marianne K. Poxleitner,Claire A. Rinehart,Courtney J. Robinson,Michael R. Rubin,Joseph N. Teyim,Edwin Vazquez,Vassie C. Ware,Jacqueline Washington,Graham F. Hatfull +43 more
TL;DR: Characterization of ten Cluster N temperate mycobacteriophages revealed at least five distinct prophage-expressed viral defence systems that interfere with the infection of lytic and temperate phages that are either closely related (homotypic defence) or unrelated (heterotypic Defence) to the prophages.
Journal ArticleDOI
Genomic and structural analysis of Syn9, a cyanophage infecting marine Prochlorococcus and Synechococcus.
Peter Weigele,Welkin H. Pope,Marisa L. Pedulla,Jennifer M. Houtz,Alexis L. Smith,James F. Conway,Jonathan King,Graham F. Hatfull,Jeffrey G. Lawrence,Roger W. Hendrix +9 more
TL;DR: Experimental and computational analyses identified genes likely involved in virion formation, nucleotide synthesis, and DNA replication and repair in Syn9 that suggest that Syn9 is well adapted to the physiology of its photosynthetic hosts and may affect the evolution of these sequences within marine cyanobacteria.