D
D. Brown
Researcher at Wellcome Trust
Publications - 5
Citations - 10512
D. Brown is an academic researcher from Wellcome Trust. The author has contributed to research in topics: Genome & Mycobacterium tuberculosis. The author has an hindex of 4, co-authored 4 publications receiving 10139 citations.
Papers
More filters
Journal ArticleDOI
Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence
Stewart T. Cole,Roland Brosch,Julian Parkhill,Thierry Garnier,Carol Churcher,David Harris,Stephen V. Gordon,Karin Eiglmeier,S. Gas,Clifton E. Barry,Fredj Tekaia,K. Badcock,D. Basham,D. Brown,Tracey Chillingworth,R. Connor,Robert L. Davies,K. Devlin,Theresa Feltwell,S. Gentles,N. Hamlin,S. Holroyd,T. Hornsby,Kay Jagels,Anders Krogh,J. McLean,Sharon Moule,Lee Murphy,K. Oliver,J. Osborne,Michael A. Quail,Marie-Adèle Rajandream,Jane Rogers,S. Rutter,K. Seeger,Jason Skelton,Rob Squares,S. Squares,John Sulston,K. Taylor,Sally Whitehead,Bart Barrell +41 more
TL;DR: The complete genome sequence of the best-characterized strain of Mycobacterium tuberculosis, H37Rv, has been determined and analysed in order to improve the understanding of the biology of this slow-growing pathogen and to help the conception of new prophylactic and therapeutic interventions.
Journal ArticleDOI
Massive gene decay in the leprosy bacillus
Stewart T. Cole,Karin Eiglmeier,Julian Parkhill,Keith D. James,Nicholas R. Thomson,Paul R. Wheeler,Nadine Honoré,Thierry Garnier,Carol Churcher,David Harris,Karen Mungall,D. Basham,D. Brown,Tracey Chillingworth,R. Connor,Robert L. Davies,K. Devlin,Stephanie Duthoy,Theresa Feltwell,Audrey Fraser,N. Hamlin,S. Holroyd,T. Hornsby,Kay Jagels,Céline Lacroix,J. Maclean,Sharon Moule,Lee Murphy,K. Oliver,Michael A. Quail,Marie-Adèle Rajandream,Kim Rutherford,S. Rutter,K. Seeger,Sylvie Simon,Mark Simmonds,Jason Skelton,Rob Squares,S. Squares,K. Stevens,K. Taylor,Sally Whitehead,J. R. Woodward,Bart Barrell +43 more
TL;DR: Comparing the 3.27-megabase genome sequence of an armadillo-derived Indian isolate of the leprosy bacillus with that of Mycobacterium tuberculosis provides clear explanations for these properties and reveals an extreme case of reductive evolution.
Journal ArticleDOI
Complete DNA sequence of a serogroup A strain of Neisseria meningitidis Z2491
Julian Parkhill,Mark Achtman,Keith D. James,Stephen D. Bentley,Carol Churcher,S R Klee,Giovanna Morelli,D. Basham,D. Brown,Tracey Chillingworth,Robert L. Davies,P. Davis,K. Devlin,Theresa Feltwell,N. Hamlin,S. Holroyd,Kay Jagels,S. Leather,Sharon Moule,Karen Mungall,Michael A. Quail,Marie-Adèle Rajandream,Kim Rutherford,Mark Simmonds,Jason Skelton,Sally Whitehead,Brian G. Spratt,Bart Barrell +27 more
TL;DR: The complete genome sequence of a serogroup A strain of Neisseria meningitidis, Z2491, is determined and the most notable feature of the genome is the presence of many hundreds of repetitive elements, ranging from short repeats, positioned either singly or in large multiple arrays, to insertion sequences and gene duplications of one kilobase or more.
Journal ArticleDOI
The complete nucleotide sequence of chromosome 3 of Plasmodium falciparum
Sharen Bowman,Daniel Lawson,D. Basham,D. Brown,Tracey Chillingworth,Carol Churcher,Alister Craig,Robert L. Davies,K. Devlin,Theresa Feltwell,S. Gentles,Rhian Gwilliam,N. Hamlin,David Harris,S. Holroyd,T. Hornsby,Paul Horrocks,Kay Jagels,Bijay Jassal,S Kyes,J. McLean,Sharon Moule,Karen Mungall,Lee Murphy,K. Oliver,Michael A. Quail,Marie-Adèle Rajandream,S. Rutter,Jason Skelton,Rob Squares,S. Squares,John Sulston,Sally Whitehead,J. R. Woodward,Chris I. Newbold,Bart Barrell +35 more
TL;DR: The sub-telomeric regions of chromosome 3 show a conserved order of features, including repetitive DNA sequences, members of multigene families involved in pathogenesis and antigenic variation, a number of conserved pseudogenes, and several genes of unknown function.
Diffractive Photoproduction of ψ(2S) Mesons at HERA H1 Collaboration
C. Adloff,V. P. Andreev,B. Andrieu,Tinne Anthonis,A. Astvatsatourov,Anton Babaev,J. Bähr,P. Baranov,E. Barrelet,W. Bartel,S. Baumgartner,Jürgen Becker,Matthew Beckingham,A. Beglarian,O. Behnke,Claus C. Beier,A.S. Belousov,Ch. Berger,T. Berndt,J.C. Bizot,J. Böhme,Vincent Boudry,W. Braunschweig,V. Brisson,H.-B. Bröker,D. Brown,W. Brückner,Dusan Bruncko,F. W. Büsser,A. Bunyatyan,A. Burrage,G. Buschhorn,L. Bystritskaya,Alan Campbell,Stan Caron,F. Cassol-Brunner,Dan Clarke,Caroline Collard,J. G. Contreras,Y.R. Coppens,Jane Coughlan,M. C. Cousinou,Bradley Cox,G. Cozzika,J. Cvach,J. B. Dainton,W.D. Dau,K. Daum,M. Davidsson,B. Delcourt,N. Delerue,R. Demirchyan,A. De Roeck,E. A. De Wolf,Cristinel Diaconu,J. C. Dingfelder,P. Dixon,V. Dodonov,J. D. Dowell,A. Droutskoi,A. Dubak,C. Duprel,Guenter Eckerlin,V. Efremenko,S. Egli,R. Eichler,F. Eisele,E. Eisenhandler,M. Ellerbrock,E. E. Elsen,Mike Erdmann,Wolfram Erdmann,P.J.W. Faulkner,Laurent Favart,A. Fedotov,R. Felst,J. Ferencei,S. Ferron,M. Fleischer,Philipp Fleischmann,Y.H. Fleming,Günter Flügge,A. M. Fomenko,I. Foresti,J. Formánek,G. Franke,G. Frising,E. Gabathuler,J. Garvey,J. Gassner,J. Gayler,R. Gerhards,C. Gerlich,S. Ghazaryan,L. Goerlich,N. Gogitidze,Christoph Grab,Varlen Grabski,Harald Grässler,T. Greenshaw,G. Grindhammer,T. Hadig,D. Haidt,L. Hajduk,J. Haller,W. J. Haynes,Beate Heinemann,G. Heinzelmann,R. C. W. Henderson,S. Hengstmann,H. Henschel,R. Heremans,L. Herrera,I. Herynek,Malte Hildebrandt,M. Hilgers,K. H. Hiller,Jan Hladky,P. Höting,Dieter H. H. Hoffmann,Roland Horisberger,A. Hovhannisyan,Stephen Hurling,M. Ibbotson,Cigdem Issever,M. Jacquet,M. Jaffré,Ludger Janauschek,Xavier Janssen,V. Jemanov,Leif J. Jönsson,C. Johnson,D.P. Johnson,M Jones,H. Jung,D. Kant,M. Kapichine,Martin Karlsson,O. Karschnick,F. Keil,N. Keller,J. Kennedy,I. R. Kenyon,S. Kermiche,C. Kiesling,P. Kjellberg,Marguerita E. Klein,Claus Kleinwort,T. Kluge,G. Knies,B. Koblitz,S. D. Kolya,V. Korbel,P. Kostka,S. K. Kotelnikov,R. Koutouev,A. Koutov,Juergen Kroseberg,Katja Krüger,T. Kuhr,T. Kurca,D. Q. Lamb,M. P. J. Landon,W. Lange,T. Laštovička,Paul Laycock,E. Lebailly,A. Lebedev,B. Leißner,R. Lemrani,V. Lendermann,S. Levonian,Mats Stefan Lindstroem,Benno List,Ewelina Lobodzinska,B. Lobodzinski,A. Loginov,N. Loktionova,V. Lubimov,S. Lüders,D. Lüke,L. Lytkin,N. Malden,E. Malinovski,Igor Malinovski,S. Mangano,Richard Maracek,Pierre Marage,J J Marks,R. Marshall,H. U. Martyn,J. Martyniak,Stephen Maxfield,D. Meer,A. Mehta,Karsten Meier,A. Meyer,Hp. Meyer,J. Meyer,P.-O. Meyer,S. Mikocki,David Milstead,S. Mohrdieck,M. N. Mondragon,F. Moreau,A. N. Morozov,J. V. Morris,K. Müller,Pavel Murin,V. Nagovizin,B. Naroska,J. Naumann,Peter R. Newman,Florian Niebergall,C. Niebuhr,O. Nix,G. Nowak,J. E. Olsson,D. Ozerov,V. Panassik,C. Pascaud,G. D. Patel,Martin Peez,Edgar Perez,A. Petrukhin,J.P. Phillips,Daniel Pitzl,R. Pöschl,I. Potachnikova,Bogdan Povh,G. Rädel,J. Rauschenberger,P. E. Reimer,B. Reisert,C. Risler,Eram Rizvi,Peter Robmann,R. Roosen,A. Rostovtsev,Sergey Rusakov,K. Rybicki,J. Samson,D. P. C. Sankey,S. Schätzel,J. Scheins,Peter Schleper,David Schmidt,Søren Schmidt,Stefan Schmitt,M. Schneider,Laurent Schoeffel,André Schöning,T. Schörner,V. Schröder,H. Ch Schultz-Coulon,C. Schwanenberger,K. Sedlák,F. Sefkow,V I. Shekelyan,I. Sheviakov,L. N. Shtarkov,Yves Sirois,T. J. Sloan,P. A. Smirnov,Y. Soloviev,David South,V. Spaskov,A. Specka,H. Spitzer +268 more
TL;DR: Results on diffractive photoproduction of ψ(2S) mesons are presented using data collected between 1996 and 2000 with the H1 detector at the HERA ep collider to describe the measurements well.