K
K. Stevens
Researcher at Wellcome Trust Sanger Institute
Publications - 18
Citations - 10388
K. Stevens is an academic researcher from Wellcome Trust Sanger Institute. The author has contributed to research in topics: Genome & Gene. The author has an hindex of 15, co-authored 18 publications receiving 10010 citations. Previous affiliations of K. Stevens include Wellcome Trust.
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Journal ArticleDOI
The genome sequence of Schizosaccharomyces pombe
Valerie Wood,R. Gwilliam,Marie-Adèle Rajandream,M. Lyne,Rachel Lyne,A. Stewart,J. Sgouros,N. Peat,Jacqueline Hayles,Stephen Baker,D. Basham,Sharen Bowman,Karen Brooks,D. Brown,Steve D.M. Brown,Tracey Chillingworth,Carol Churcher,Mark O. Collins,R. Connor,Ann Cronin,P. Davis,Theresa Feltwell,Andrew G. Fraser,S. Gentles,Arlette Goble,N. Hamlin,David Harris,J. Hidalgo,Geoffrey M. Hodgson,S. Holroyd,T. Hornsby,S. Howarth,Elizabeth J. Huckle,Sarah E. Hunt,Kay Jagels,Kylie R. James,L. Jones,Matthew Jones,S. Leather,S. McDonald,J. McLean,P. Mooney,Sharon Moule,Karen Mungall,Lee Murphy,D. Niblett,C. Odell,Karen Oliver,Susan O'Neil,D. Pearson,Michael A. Quail,Ester Rabbinowitsch,Kim Rutherford,Simon Rutter,David L. Saunders,Kathy Seeger,Sarah Sharp,Jason Skelton,Mark Simmonds,R. Squares,S. Squares,K. Stevens,K. Taylor,Ruth Taylor,Adrian Tivey,S. Walsh,T. Warren,S. Whitehead,John Woodward,Guido Volckaert,Rita Aert,Johan Robben,B. Grymonprez,I. Weltjens,E. Vanstreels,Michael A. Rieger,M. Schafer,S. Muller-Auer,C. Gabel,M. Fuchs,C. Fritzc,E. Holzer,D. Moestl,H. Hilbert,K. Borzym,I. Langer,Alfred Beck,Hans Lehrach,Richard Reinhardt,Thomas M. Pohl,P. Eger,Wolfgang Zimmermann,H. Wedler,R. Wambutt,Bénédicte Purnelle,André Goffeau,Edouard Cadieu,Stéphane Dréano,Stéphanie Gloux,Valerie Lelaure,Stéphanie Mottier,Francis Galibert,Stephen J. Aves,Z. Xiang,Cherryl Hunt,Karen Moore,S. M. Hurst,M. Lucas,M. Rochet,Claude Gaillardin,Victor A. Tallada,Victor A. Tallada,Andrés Garzón,Andrés Garzón,G. Thode,Rafael R. Daga,Rafael R. Daga,L. Cruzado,Juan Jimenez,Juan Jimenez,Miguel del Nogal Sánchez,F. del Rey,J. Benito,Angel Domínguez,José L. Revuelta,Sergio Moreno,John Armstrong,Susan L. Forsburg,L. Cerrutti,Todd M. Lowe,W. R. McCombie,Ian T. Paulsen,Judith A. Potashkin,G. V. Shpakovski,David W. Ussery,Bart Barrell,Paul Nurse +136 more
TL;DR: The genome of fission yeast (Schizosaccharomyces pombe), which contains the smallest number of protein-coding genes yet recorded for a eukaryote, is sequenced and highly conserved genes important for eukARYotic cell organization including those required for the cytoskeleton, compartmentation, cell-cycle control, proteolysis, protein phosphorylation and RNA splicing are identified.
Journal ArticleDOI
Massive gene decay in the leprosy bacillus
Stewart T. Cole,Karin Eiglmeier,Julian Parkhill,Keith D. James,Nicholas R. Thomson,Paul R. Wheeler,Nadine Honoré,Thierry Garnier,Carol Churcher,David Harris,Karen Mungall,D. Basham,D. Brown,Tracey Chillingworth,R. Connor,Robert L. Davies,K. Devlin,Stephanie Duthoy,Theresa Feltwell,Audrey Fraser,N. Hamlin,S. Holroyd,T. Hornsby,Kay Jagels,Céline Lacroix,J. Maclean,Sharon Moule,Lee Murphy,K. Oliver,Michael A. Quail,Marie-Adèle Rajandream,Kim Rutherford,S. Rutter,K. Seeger,Sylvie Simon,Mark Simmonds,Jason Skelton,Rob Squares,S. Squares,K. Stevens,K. Taylor,Sally Whitehead,J. R. Woodward,Bart Barrell +43 more
TL;DR: Comparing the 3.27-megabase genome sequence of an armadillo-derived Indian isolate of the leprosy bacillus with that of Mycobacterium tuberculosis provides clear explanations for these properties and reveals an extreme case of reductive evolution.
Journal ArticleDOI
Complete genome sequence of a multiple drug resistant Salmonella enterica serovar Typhi CT18
Julian Parkhill,Gordon Dougan,Keith D. James,Nicholas R. Thomson,Derek Pickard,John Wain,Carol Churcher,Karen Mungall,Stephen D. Bentley,Matthew T. G. Holden,Mohammed Sebaihia,Stephen Baker,D. Basham,Karen Brooks,Tracey Chillingworth,Phillippa L. Connerton,A. Cronin,P. Davis,Robert L. Davies,L. Dowd,Nicholas J. White,Jeremy Farrar,Theresa Feltwell,N. Hamlin,Ashraful Haque,Tran Tinh Hien,S. Holroyd,Kay Jagels,Anders Krogh,Torben Larsen,S. Leather,Sharon Moule,Peadar O'Gaora,Christopher M. Parry,Michael A. Quail,Kim Rutherford,Mark Simmonds,Jason Skelton,K. Stevens,Sally Whitehead,Bart Barrell +40 more
TL;DR: The genome sequence is sequenced of a S. typhi (CT18) that is resistant to multiple drugs, revealing the presence of hundreds of insertions and deletions compared with the Escherichia coli genome, ranging in size from single genes to large islands.
Journal ArticleDOI
Genome sequence of Yersinia pestis , the causative agent of plague
Julian Parkhill,Brendan W. Wren,Nicholas R. Thomson,Richard W. Titball,Matthew T. G. Holden,Michael B. Prentice,Mohammed Sebaihia,Keith D. James,Carol Churcher,Karen Mungall,Stephen Baker,D. Basham,Stephen D. Bentley,Karen Brooks,Ana Cerdeño-Tárraga,Tracey Chillingworth,A. Cronin,Robert L. Davies,P. Davis,Gordon Dougan,Theresa Feltwell,N. Hamlin,S. Holroyd,Kay Jagels,Andrey V. Karlyshev,S. Leather,Sharon Moule,P. C. F. Oyston,Michael A. Quail,Kim Rutherford,Mark Simmonds,Jason Skelton,K. Stevens,Sally Whitehead,Bart Barrell +34 more
TL;DR: The evidence of ongoing genome fluidity, expansion and decay suggests Y. pestis is a pathogen that has undergone large-scale genetic flux and provides a unique insight into the ways in which new and highly virulent pathogens evolve.
Journal ArticleDOI
Complete genomes of two clinical Staphylococcus aureus strains: Evidence for the rapid evolution of virulence and drug resistance
Matthew T. G. Holden,Edward J. Feil,Jodi A. Lindsay,Sharon J. Peacock,Nicholas P. J. Day,Mark C. Enright,Timothy J. Foster,Catrin E. Moore,Laurence D. Hurst,Rebecca Atkin,Andrew Barron,Nathalie Bason,Stephen D. Bentley,Carol Chillingworth,Tracey Chillingworth,Carol Churcher,Louise Clark,Craig Corton,Ann Cronin,Jon Doggett,Linda Dowd,Theresa Feltwell,Zahra Hance,Barbara Harris,Heidi Hauser,S. Holroyd,Kay Jagels,Keith D. James,Nicola Lennard,Alexandra Line,Rebecca Mayes,Sharon Moule,Karen Mungall,Douglas Ormond,Michael A. Quail,Ester Rabbinowitsch,Kim Rutherford,Mandy Sanders,Sarah Sharp,Mark Simmonds,K. Stevens,Sally Whitehead,Bart Barrell,Brian G. Spratt,Julian Parkhill +44 more
TL;DR: The crucial role that accessory elements play in the rapid evolution of S. aureus is clearly illustrated by comparing the MSSA476 genome with that of an extremely closely related MRSA community-acquired strain; the differential distribution of large mobile elements carrying virulence and drug-resistance determinants may be responsible for the clinically important phenotypic differences in these strains.