S
Sharen Bowman
Researcher at Wellcome Trust
Publications - 14
Citations - 6849
Sharen Bowman is an academic researcher from Wellcome Trust. The author has contributed to research in topics: Genome & Schizosaccharomyces pombe. The author has an hindex of 10, co-authored 14 publications receiving 6538 citations. Previous affiliations of Sharen Bowman include Wellcome Trust Sanger Institute & J. Craig Venter Institute.
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Journal ArticleDOI
Genome sequence of the human malaria parasite Plasmodium falciparum
Malcolm J. Gardner,Neil Hall,Eula Fung,Owen White,Matthew Berriman,Richard W. Hyman,Jane M. Carlton,Arnab Pain,Karen E. Nelson,Sharen Bowman,Ian T. Paulsen,Keith D. James,Jonathan A. Eisen,Kim Rutherford,Steven L. Salzberg,Alister Craig,Sue Kyes,Man Suen Chan,Vishvanath Nene,Shamira J. Shallom,Bernard B. Suh,Jeremy Peterson,Samuel V. Angiuoli,Mihaela Pertea,Jonathan E. Allen,Jeremy D. Selengut,Daniel H. Haft,Michael W. Mather,Akhil B. Vaidya,David M. A. Martin,Alan H. Fairlamb,Martin Fraunholz,David S. Roos,Stuart A. Ralph,Geoffrey I. McFadden,Leda M. Cummings,G. Mani Subramanian,Christopher J. Mungall,J. Craig Venter,Daniel J. Carucci,Stephen L. Hoffman,Chris I. Newbold,Ronald W. Davis,Claire M. Fraser,Bart Barrell +44 more
TL;DR: The genome sequence of P. falciparum clone 3D7 is reported, which is the most (A + T)-rich genome sequenced to date and is being exploited in the search for new drugs and vaccines to fight malaria.
Journal ArticleDOI
The genome sequence of Schizosaccharomyces pombe
Valerie Wood,R. Gwilliam,Marie-Adèle Rajandream,M. Lyne,Rachel Lyne,A. Stewart,J. Sgouros,N. Peat,Jacqueline Hayles,Stephen Baker,D. Basham,Sharen Bowman,Karen Brooks,D. Brown,Steve D.M. Brown,Tracey Chillingworth,Carol Churcher,Mark O. Collins,R. Connor,Ann Cronin,P. Davis,Theresa Feltwell,Andrew G. Fraser,S. Gentles,Arlette Goble,N. Hamlin,David Harris,J. Hidalgo,Geoffrey M. Hodgson,S. Holroyd,T. Hornsby,S. Howarth,Elizabeth J. Huckle,Sarah E. Hunt,Kay Jagels,Kylie R. James,L. Jones,Matthew Jones,S. Leather,S. McDonald,J. McLean,P. Mooney,Sharon Moule,Karen Mungall,Lee Murphy,D. Niblett,C. Odell,Karen Oliver,Susan O'Neil,D. Pearson,Michael A. Quail,Ester Rabbinowitsch,Kim Rutherford,Simon Rutter,David L. Saunders,Kathy Seeger,Sarah Sharp,Jason Skelton,Mark Simmonds,R. Squares,S. Squares,K. Stevens,K. Taylor,Ruth Taylor,Adrian Tivey,S. Walsh,T. Warren,S. Whitehead,John Woodward,Guido Volckaert,Rita Aert,Johan Robben,B. Grymonprez,I. Weltjens,E. Vanstreels,Michael A. Rieger,M. Schafer,S. Muller-Auer,C. Gabel,M. Fuchs,C. Fritzc,E. Holzer,D. Moestl,H. Hilbert,K. Borzym,I. Langer,Alfred Beck,Hans Lehrach,Richard Reinhardt,Thomas M. Pohl,P. Eger,Wolfgang Zimmermann,H. Wedler,R. Wambutt,Bénédicte Purnelle,André Goffeau,Edouard Cadieu,Stéphane Dréano,Stéphanie Gloux,Valerie Lelaure,Stéphanie Mottier,Francis Galibert,Stephen J. Aves,Z. Xiang,Cherryl Hunt,Karen Moore,S. M. Hurst,M. Lucas,M. Rochet,Claude Gaillardin,Victor A. Tallada,Victor A. Tallada,Andrés Garzón,Andrés Garzón,G. Thode,Rafael R. Daga,Rafael R. Daga,L. Cruzado,Juan Jimenez,Juan Jimenez,Miguel del Nogal Sánchez,F. del Rey,J. Benito,Angel Domínguez,José L. Revuelta,Sergio Moreno,John Armstrong,Susan L. Forsburg,L. Cerrutti,Todd M. Lowe,W. R. McCombie,Ian T. Paulsen,Judith A. Potashkin,G. V. Shpakovski,David W. Ussery,Bart Barrell,Paul Nurse +136 more
TL;DR: The genome of fission yeast (Schizosaccharomyces pombe), which contains the smallest number of protein-coding genes yet recorded for a eukaryote, is sequenced and highly conserved genes important for eukARYotic cell organization including those required for the cytoskeleton, compartmentation, cell-cycle control, proteolysis, protein phosphorylation and RNA splicing are identified.
Journal ArticleDOI
The complete nucleotide sequence of chromosome 3 of Plasmodium falciparum
Sharen Bowman,Daniel Lawson,D. Basham,D. Brown,Tracey Chillingworth,Carol Churcher,Alister Craig,Robert L. Davies,K. Devlin,Theresa Feltwell,S. Gentles,Rhian Gwilliam,N. Hamlin,David Harris,S. Holroyd,T. Hornsby,Paul Horrocks,Kay Jagels,Bijay Jassal,S Kyes,J. McLean,Sharon Moule,Karen Mungall,Lee Murphy,K. Oliver,Michael A. Quail,Marie-Adèle Rajandream,S. Rutter,Jason Skelton,Rob Squares,S. Squares,John Sulston,Sally Whitehead,J. R. Woodward,Chris I. Newbold,Bart Barrell +35 more
TL;DR: The sub-telomeric regions of chromosome 3 show a conserved order of features, including repetitive DNA sequences, members of multigene families involved in pathogenesis and antigenic variation, a number of conserved pseudogenes, and several genes of unknown function.
Journal ArticleDOI
A superfamily of variant genes encoded in the subtelomeric region of Plasmodium vivax
Hernando A. del Portillo,Carmen Fernandez-Becerra,Sharen Bowman,K. Oliver,Martin Preuss,Cecilia P. Sanchez,Nick K. Schneider,Juan Miguel Villalobos,Marie-Adèle Rajandream,David Harris,Luiz Hildebrando Pereira da Silva,Bart Barrell,Michael Lanzer +12 more
TL;DR: Vir genes are identified, through the analysis of a continuous 155,711-base-pair sequence of a P. vivax chromosome end, a multigene family called vir, which is specific to P.vivax, indicating that they may have a functional role in establishing chronic infection through antigenic variation.
Journal ArticleDOI
The architecture of variant surface glycoprotein gene expression sites in Trypanosoma brucei.
Matthew Berriman,Neil Hall,Karen Sheader,Frédéric Bringaud,Bela Tiwari,Tomoko Isobe,Sharen Bowman,Craig Corton,Louise Clark,George A. M. Cross,Maarten Hoek,Tyiesha Zanders,Magali Berberof,Piet Borst,Gloria Rudenko +14 more
TL;DR: Unexpected conservation of sequences, including pseudogenes, indicates that the multiple ESs could have arisen through a relatively recent amplification of a single ES.