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Yusuke Murata
Researcher at Kumamoto University
Publications - 6
Citations - 389
Yusuke Murata is an academic researcher from Kumamoto University. The author has contributed to research in topics: Insulin receptor & Insulin-like growth factor 1 receptor. The author has an hindex of 6, co-authored 6 publications receiving 364 citations.
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Journal ArticleDOI
Statins Activate Peroxisome Proliferator-Activated Receptor γ Through Extracellular Signal-Regulated Kinase 1/2 and p38 Mitogen-Activated Protein Kinase-Dependent Cyclooxygenase-2 Expression in Macrophages
Miyuki Yano,Takeshi Matsumura,Takafumi Senokuchi,Norio Ishii,Yusuke Murata,Kayo Taketa,Hiroyuki Motoshima,Tetsuya Taguchi,Kazuhiro Sonoda,Daisuke Kukidome,Yoh Takuwa,Teruo Kawada,Michael Brownlee,Takeshi Nishikawa,Eiichi Araki +14 more
TL;DR: It is demonstrated that statins inhibited lipopolysaccharide-induced tumor necrosis factor α or monocyte chemoattractant protein-1 mRNA expression, and these effects by statins were abrogated by the PPARγ antagonist T0070907 or by small interfering RNA of PPARβ or PPARα.
Journal ArticleDOI
Inherited adrenocorticotropin-independent macronodular adrenal hyperplasia with abnormal cortisol secretion by vasopressin and catecholamines: detection of the aberrant hormone receptors on adrenal gland.
Nobuhiro Miyamura,Tetsuya Taguchi,Yusuke Murata,Kayo Taketa,Shinsuke Iwashita,Kazuya Matsumoto,Takeshi Nishikawa,Tetsushi Toyonaga,Michiharu Sakakida,Eiichi Araki +9 more
TL;DR: An intervention could be tried to prevent the development of overt Cushing’s syndrome by suppression of the possible endogenous ligands or by blockade of the receptors that may be aberrantly expressed in his adrenal glands.
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Oxidized Low Density Lipoprotein Activates Peroxisome Proliferator-activated Receptor-α (PPARα) and PPARγ through MAPK-dependent COX-2 Expression in Macrophages
Kayo Taketa,Takeshi Matsumura,Miyuki Yano,Norio Ishii,Takafumi Senokuchi,Hiroyuki Motoshima,Yusuke Murata,Shokei Kim-Mitsuyama,Teruo Kawada,Hiroyuki Itabe,Motohiro Takeya,Takeshi Nishikawa,Kaku Tsuruzoe,Eiichi Araki +13 more
TL;DR: Ox-LDL-induced increase in 15d-PGJ2 level through ERK1/2-dependent COX-2 expression is one of the mechanisms of PPARα and PPARγ activation in macrophages, and may control excess atherosclerotic progression.
Journal ArticleDOI
AICAR, an activator of AMP-activated protein kinase, down-regulates the insulin receptor expression in HepG2 cells
Kazuhiko Nakamaru,K. Matsumoto,Tetsuya Taguchi,Mihoshi Suefuji,Yusuke Murata,Motoyuki Igata,Junji Kawashima,Tatsuya Kondo,Hiroyuki Motoshima,Kaku Tsuruzoe,Nobuhiro Miyamura,Tetsushi Toyonaga,Eiichi Araki +12 more
TL;DR: It is suggested, for the first time, that AMPK activation could reduce the expression of insulin receptor, at least in part, by a down-regulation of the transcriptional level, and this effect may be liver specific.
Journal ArticleDOI
IRS-1 transgenic mice show increased epididymal fat mass and insulin resistance.
Yusuke Murata,Kaku Tsuruzoe,Junji Kawashima,Noboru Furukawa,Tatsuya Kondo,Hiroyuki Motoshima,Motoyuki Igata,Kayo Taketa,Kazunari Sasaki,Hideki Kishikawa,C. Ronald Kahn,Tetsushi Toyonaga,Eiichi Araki +12 more
TL;DR: The results suggest that excess IRS-1 expression may not provide a beneficial impact on glucose homeostasis in vivo, and insulin signaling was significantly attenuated in the liver of IRS- 1-Tg mice, which may contribute to the glucose intolerance.