Tapinarof Is a Natural AhR Agonist that Resolves Skin Inflammation in Mice and Humans
Susan H. Smith,Channa K Jayawickreme,David J. Rickard,Edwige Nicodeme,Thi Bui,Cathy Simmons,Christine M. Coquery,Jessica Neil,William M. Pryor,David L. Mayhew,Deepak K. Rajpal,Katrina L. Creech,Sylvia Furst,James Lee,Dalei Wu,Fraydoon Rastinejad,Timothy M. Willson,Fabrice Viviani,David C. Morris,John T. Moore,Javier Cote-Sierra +20 more
TLDR
These studies identify tapinarof as an AhR agonist and confirm that its efficacy is dependent on AhR.About:
This article is published in Journal of Investigative Dermatology.The article was published on 2017-10-01 and is currently open access. It has received 197 citations till now. The article focuses on the topics: Aryl hydrocarbon receptor & Proinflammatory cytokine.read more
Citations
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The aryl hydrocarbon receptor: an environmental sensor integrating immune responses in health and disease.
TL;DR: The role of AHR in autoimmune and neoplastic diseases of the central nervous system, with a special focus on the gut immune system, the gut–brain axis and the therapeutic potential of targeting A HR in neurological disorders are discussed.
Journal ArticleDOI
The aryl hydrocarbon receptor as a target of environmental stressors - Implications for pollution mediated stress and inflammatory responses.
TL;DR: Findings showing the critical role that the AHR plays in mediating effects of environmental pollutants and stressors, which pose a risk of impacting the environment and human health are summarized.
Journal ArticleDOI
Atopic dermatitis: an expanding therapeutic pipeline for a complex disease.
TL;DR: The potential for a precision medicine approach to enable prevention and more effective long-term control of atopic dermatitis (AD) has been highlighted in this paper, where a review of various strategies and novel agents currently being investigated for AD is presented.
Journal ArticleDOI
Regulation of Filaggrin, Loricrin, and Involucrin by IL-4, IL-13, IL-17A, IL-22, AHR, and NRF2: Pathogenic Implications in Atopic Dermatitis
TL;DR: The mechanisms by which FLG, LOR, and IVL expression is regulated by IL-4, IL-13,IL-22, and IL-17A are focused on and how AHR and NRF2 dual activators exert their beneficial effects in the treatment of AD is summarized.
Journal ArticleDOI
The Role of the Aryl Hydrocarbon Receptor (AHR) in Immune and Inflammatory Diseases.
TL;DR: It is found that SNPs that are outside of nuclear receptor binding sites (i.e., outside of AHR response elements (AHREs) may contribute to AHR-dependent gene regulation in a SNP- and ligand-dependent manner.
References
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Journal ArticleDOI
Interleukin-22, a T H 17 cytokine, mediates IL-23-induced dermal inflammation and acanthosis
Yan Zheng,Dimitry M. Danilenko,Patricia Valdez,Ian Kasman,Jeffrey Eastham-Anderson,Jianfeng Wu,Wenjun Ouyang +6 more
TL;DR: The results suggest that TH17 cells, through the production of both IL-22 and IL-17, might have essential functions in host defence and in the pathogenesis of autoimmune diseases such as psoriasis.
Journal ArticleDOI
Activation of the aryl hydrocarbon receptor by structurally diverse exogenous and endogenous chemicals.
Michael S. Denison,Scott R. Nagy +1 more
TL;DR: Evidence for the structural promiscuity of AhR ligand binding is described and the current state of knowledge with regards to the activation of the AhR signaling pathway by naturally occurring exogenous and endogenous ligands is discussed.
Journal ArticleDOI
Control of T reg and T H 17 cell differentiation by the aryl hydrocarbon receptor
Francisco J. Quintana,Alexandre S. Basso,Antonio Iglesias,Thomas Korn,Mauricio F. Farez,Estelle Bettelli,Mario Caccamo,Mohamed Oukka,Howard L. Weiner +8 more
TL;DR: The identification of the ligand-activated transcription factor aryl hydrocarbon receptor (AHR) as a regulator of Treg and TH17 cell differentiation in mice is reported, constituting a unique target for therapeutic immunomodulation.
Journal ArticleDOI
The aryl hydrocarbon receptor links TH17-cell-mediated autoimmunity to environmental toxins.
Marc Veldhoen,Keiji Hirota,Astrid M. Westendorf,Jan Buer,Laure Dumoutier,Jean-Christophe Renauld,Brigitta Stockinger +6 more
TL;DR: It is shown that in the CD4+ T-cell lineage of mice AHR expression is restricted to the TH17 cell subset and its ligation results in the production of the TH16 cytokine interleukin (IL)-22, and AHR ligands may represent co-factors in the development of autoimmune diseases.
Journal ArticleDOI
Immunology of Psoriasis
TL;DR: The genetic background of psoriasis and its relationship to immune function, specifically genetic mutations, key PSORS loci, single nucleotide polymorphisms, and the skin transcriptome are discussed.
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