D
Daniel C. Jans
Researcher at Royal Institute of Technology
Publications - 21
Citations - 1489
Daniel C. Jans is an academic researcher from Royal Institute of Technology. The author has contributed to research in topics: Translocase of the inner membrane & Mitochondrion. The author has an hindex of 15, co-authored 20 publications receiving 1198 citations. Previous affiliations of Daniel C. Jans include Max Planck Society & University of Göttingen.
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Journal ArticleDOI
Bax assembles into large ring-like structures remodeling the mitochondrial outer membrane in apoptosis
TL;DR: It is demonstrated that activated Bax molecules, besides forming large and compact clusters, also assemble, potentially with other proteins including Bak, into ring‐like structures in the mitochondrial outer membrane, and that at least in Drp1 knockdown cells, these assemblies are not sufficient for full cytochrome c release.
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Rcf1 mediates cytochrome oxidase assembly and respirasome formation, revealing heterogeneity of the enzyme complex.
Milena Vukotic,Milena Vukotic,Silke Oeljeklaus,Sebastian Wiese,F.-Nora Vögtle,Chris Meisinger,Helmut E. Meyer,Anke Zieseniss,D. M. Katschinski,Daniel C. Jans,Stefan Jakobs,Stefan Jakobs,Bettina Warscheid,Peter Rehling,Peter Rehling,Markus Deckers +15 more
TL;DR: It is revealed that the cytochrome oxidase of mitochondria displays intrinsic heterogeneity with regard to its subunit composition and that distinct forms of respirasomes can be formed by complex variants.
Journal ArticleDOI
MINOS1 is a conserved component of mitofilin complexes and required for mitochondrial function and cristae organization.
Alwaleed K. Alkhaja,Daniel C. Jans,Miroslav Nikolov,Milena Vukotic,Oleksandr Lytovchenko,Fabian Ludewig,Wolfgang Schliebs,Dietmar Riedel,Henning Urlaub,Stefan Jakobs,Markus Deckers +10 more
TL;DR: MINOS1/Mio10 is a novel constituent of the mitofilin/Fcj1 complex of the inner membrane, linking the morphology phenotype of the mutant to the activity of the mitochondrial inner membrane organizing complex.
Journal ArticleDOI
STED super-resolution microscopy reveals an array of MINOS clusters along human mitochondria
Daniel C. Jans,Christian A. Wurm,Dietmar Riedel,Dirk Wenzel,Franziska Stagge,Markus Deckers,Peter Rehling,Stefan Jakobs +7 more
TL;DR: The super-resolution images demonstrate an unexpectedly high level of regularity in the nanoscale distribution of the MINOS complex in human mitochondria, supporting an integrating role of MINOS in the structural organization of the organelle.
Journal ArticleDOI
Breast cancer quantitative proteome and proteogenomic landscape
Henrik J. Johansson,Fabio Socciarelli,Nathaniel M. Vacanti,Nathaniel M. Vacanti,Mads H. Haugen,Yafeng Zhu,Ioannis Siavelis,Alejandro Fernandez-Woodbridge,Miriam Ragle Aure,Bengt Sennblad,Mattias Vesterlund,Rui M. M. Branca,Lukas M. Orre,Mikael Huss,Erik Fredlund,Elsa Beraki,Øystein Garred,Jorrit Boekel,Torill Sauer,Wei Zhao,Silje Nord,Elen K. Höglander,Daniel C. Jans,Hjalmar Brismar,Hjalmar Brismar,Tonje Husby Haukaas,Tone Frost Bathen,Ellen Schlichting,Bjørn Naume,Torben Lüders,Torben Lüders,Elin Borgen,Vessela N. Kristensen,Vessela N. Kristensen,Vessela N. Kristensen,Hege G. Russnes,Ole Christian Lingjærde,Ole Christian Lingjærde,Gordon B. Mills,Kristine Kleivi Sahlberg,Kristine Kleivi Sahlberg,Anne Lise Børresen-Dale,Anne Lise Børresen-Dale,Janne Lehtiö +43 more
TL;DR: An in-depth quantitative profiling of the proteome of 45 breast tumors is performed, and the authors show they can recapitulate the transcriptome-based classifications and identify many potentially antigenic tumour-specific peptides.