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Rhianna C. Laker
Researcher at University of Copenhagen
Publications - 32
Citations - 2042
Rhianna C. Laker is an academic researcher from University of Copenhagen. The author has contributed to research in topics: Skeletal muscle & Mitophagy. The author has an hindex of 19, co-authored 32 publications receiving 1557 citations. Previous affiliations of Rhianna C. Laker include University of Virginia & University of Melbourne.
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Journal ArticleDOI
Autophagy is required for exercise training-induced skeletal muscle adaptation and improvement of physical performance
Vitor A. Lira,Mitsuharu Okutsu,Mei Zhang,Nicholas P. Greene,Rhianna C. Laker,David S. Breen,Kyle L. Hoehn,Zhen Yan +7 more
TL;DR: It is demonstrated that increased basal autophagy is required for endurance exercise training‐induced skeletal muscle adaptation and improvement of physical performance and revealed that endurance exerciseTraining‐induced increases in basal autophile, including mitophagy, only take place if an enhanced oxidative phenotype is achieved.
Journal ArticleDOI
Ampk phosphorylation of Ulk1 is required for targeting of mitochondria to lysosomes in exercise-induced mitophagy
Rhianna C. Laker,Joshua C. Drake,Rebecca J. Wilson,Vitor A. Lira,Vitor A. Lira,Bevan M. Lewellen,Karen A. Ryall,Carleigh C. Fisher,Mei Zhang,Jeffrey J. Saucerman,Laurie J. Goodyear,Mondira Kundu,Zhen Yan +12 more
TL;DR: It is shown that acute treadmill running in mice causes mitochondrial oxidative stress at 3–12 h and mitophagy at 6’h post-exercise in skeletal muscle and that Ulk1 activation is dependent on Ampk, and that exercise-induced metabolic adaptation requiresUlk1.
Journal ArticleDOI
A novel mitotimer reporter gene for mitochondrial content, structure, stress, and damage in vivo
Rhianna C. Laker,Peng Xu,Karen A. Ryall,Alyson Sujkowski,Brandon M. Kenwood,Kristopher H. Chain,Mei Zhang,Mary Anne Royal,Kyle L. Hoehn,Monica Driscoll,Paul N. Adler,Robert Wessells,Jeffrey J. Saucerman,Zhen Yan +13 more
TL;DR: A reporter gene, MitoTimer, which targets mitochondria, and fluoresces green and shifts to red when oxidized, for assessment of mitochondrial content, structure, stress, and damage under physiological and pathological conditions and will be highly useful for future research of mitochondrial health in multiple disciplines in vivo.
Journal ArticleDOI
Exercise prevents maternal high-fat diet-induced hypermethylation of the Pgc-1α gene and age-dependent metabolic dysfunction in the offspring.
Rhianna C. Laker,Travis S. Lillard,Mitsuharu Okutsu,Mitsuharu Okutsu,Mei Zhang,Mei Zhang,Kyle L. Hoehn,Jessica J. Connelly,Zhen Yan +8 more
TL;DR: Maternal exercise prevented maternal HFD-induced PGC-1α hypermethylation and enhanced Pgc-1 α and its target gene expression, concurrent with amelioration of age-associated metabolic dysfunction at 9 months of age in the offspring.
Journal ArticleDOI
Time of Exercise Specifies the Impact on Muscle Metabolic Pathways and Systemic Energy Homeostasis
Shogo Sato,Astrid L. Basse,Milena Schönke,Siwei Chen,Muntaha Samad,Ali Altıntaş,Rhianna C. Laker,Emilie Dalbram,Romain Barrès,Pierre Baldi,Jonas T. Treebak,Juleen R. Zierath,Juleen R. Zierath,Paolo Sassone-Corsi +13 more
TL;DR: It is demonstrated that the time of day is a critical factor to amplify the beneficial impact of exercise on both metabolic pathways within skeletal muscle and systemic energy homeostasis.