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Daniela Gradinaru
Researcher at Carol Davila University of Medicine and Pharmacy
Publications - 51
Citations - 1726
Daniela Gradinaru is an academic researcher from Carol Davila University of Medicine and Pharmacy. The author has contributed to research in topics: Oxidative stress & Medicine. The author has an hindex of 20, co-authored 46 publications receiving 1417 citations. Previous affiliations of Daniela Gradinaru include University of Burgundy & Yahoo!.
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Journal ArticleDOI
The Akt pathway in oncology therapy and beyond (Review)
George Mihai Nitulescu,Maryna van de Venter,Georgiana Nitulescu,Anca Ungurianu,Petras Juzenas,Qian Peng,Octavian Tudorel Olaru,Daniela Gradinaru,Aristides M. Tsatsakis,Dimitris Tsoukalas,Demetrios A. Spandidos,Denisa Margina +11 more
TL;DR: This review presents key features of Akt structure and functions, and presents the progress ofAkt inhibitors in regards to drug development, and their preclinical and clinical activity in regard to therapeutic efficacy and safety for patients.
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MARK-AGE biomarkers of ageing
Alexander Bürkle,Maria Moreno-Villanueva,Jürgen Bernhard,Maria A. Blasco,Gerben Zondag,Jan H.J. Hoeijmakers,Olivier Toussaint,Beatrix Grubeck-Loebenstein,Eugenio Mocchegiani,Sebastiano Collino,Efstathios S. Gonos,Ewa Sikora,Daniela Gradinaru,Martijn E.T. Dollé,Michel Salmon,Peter Kristensen,Helen R. Griffiths,Claude Libert,Tilman Grune,Nicolle Breusing,Andreas Simm,Claudio Franceschi,Miriam Capri,Duncan Talbot,Paola Caiafa,Bertrand Friguet,P. Eline Slagboom,Antti Hervonen,Mikko Hurme,Richard Aspinall +29 more
TL;DR: The recently completed MARK-AGE study was a large-scale integrated project supported by the European Commission to identify a set of biomarkers of ageing which, as a combination of parameters with appropriate weighting, would measure biological age better than any marker in isolation.
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Chronic Monosodium Glutamate Administration Induced Hyperalgesia in Mice.
Anca Zanfirescu,Aurelia Nicoleta Cristea,George Mihai Nitulescu,Bruno Stefan Velescu,Daniela Gradinaru +4 more
TL;DR: Investigating the effect of MSG on the nociceptive threshold when given orally to mice found that a dose of 300 mg/kg MSG given for 21 days reduces the pain threshold and is associated with a significant increase in brain NO level.
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Oxidized LDL and NO synthesis--Biomarkers of endothelial dysfunction and ageing
TL;DR: This review explores recent literature on molecular mechanisms and pathophysiological relationships between LDL oxidation, NO synthesis and vascular endothelium function/dysfunction in ageing and finds evidences supporting the importance of oxidized LDL and NO activity as relevant biomarkers in vascular ageing and age-related diseases.
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Drug transport into the mammalian brain: the nasal pathway and its specific metabolic barrier.
Alain Minn,Séverine Leclerc,Jean-Marie Heydel,Anne-Laure Minn,Claire Denizot,Martine Cattarelli,Patrick Netter,Daniela Gradinaru +7 more
TL;DR: This short review summarizes recent knowledge on factors controlling the nasal pathway, focusing on drug metabolising enzymes in olfactory mucosa, Olfactory bulb and brain, which should constitute a CNS metabolic barrier.