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Daniela Penzkofer
Researcher at Goethe University Frankfurt
Publications - 7
Citations - 483
Daniela Penzkofer is an academic researcher from Goethe University Frankfurt. The author has contributed to research in topics: Reperfusion injury & Ischemia. The author has an hindex of 5, co-authored 7 publications receiving 424 citations.
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Journal ArticleDOI
Inhibition of MicroRNA-92a Protects Against Ischemia/Reperfusion Injury in a Large-Animal Model
Rabea Hinkel,Daniela Penzkofer,Stephanie Zühlke,Ariane Fischer,Wira Husada,Quan-Fu Xu,Elisabeth Baloch,Eva van Rooij,Andreas M. Zeiher,Christian Kupatt,Stefanie Dimmeler +10 more
TL;DR: Regional LNA-92a delivery reduces miR- 92a levels and infarct size and postischemic loss of function and might be a novel therapeutic tool to preserve cardiac function after ischemia.
Journal ArticleDOI
Inhibition of miR-92a improves re-endothelialization and prevents neointima formation following vascular injury.
Jan Marcus Daniel,Daniela Penzkofer,Rebecca Teske,Jochen Dutzmann,Alexander Koch,Wiebke Bielenberg,Angelika Bonauer,Reinier A. Boon,Ariane Fischer,Johann Bauersachs,Eva van Rooij,Stefanie Dimmeler,Daniel Sedding +12 more
TL;DR: It is indicated that inhibition of endothelial miR-92a attenuates neointimal lesion formation by accelerating re-endothelialization and thus represents a putative novel mechanism to enhance the functional recovery following vascular injury.
Journal ArticleDOI
The Early Activation of Toll-Like Receptor (TLR)-3 Initiates Kidney Injury after Ischemia and Reperfusion
Patrick Paulus,Katrin Rupprecht,Patrick C. Baer,Nicholas Obermüller,Daniela Penzkofer,Christin Reissig,Bertram Scheller,Johannes Holfeld,Kai Zacharowski,Stefanie Dimmeler,Joelle Schlammes,Anja Urbschat +11 more
TL;DR: Overall, the absence of TLR-3 is associated with lower cumulative kidney damage and maintained renal blood perfusion within the first 24 hours of reperfusion and it is concluded that TLr-3 seems to participate in the pathogenesis of early acute kidney injury.
Journal ArticleDOI
Phenotypic Characterization of miR-92a−/− Mice Reveals an Important Function of miR-92a in Skeletal Development
Daniela Penzkofer,Angelika Bonauer,Ariane Fischer,Alexander Tups,Ralf P. Brandes,Andreas M. Zeiher,Stefanie Dimmeler +6 more
TL;DR: It is demonstrated that deletion of miR-92a is sufficient to induce a developmental skeletal defect in mice and not reduce circulating or bone marrow-derived hematopoietic cells, but induces skeletal defects.
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The small fibrinopeptide Bβ15-42 as renoprotective agent preserving the endothelial and vascular integrity in early ischemia reperfusion injury in the mouse kidney.
Anja Urbschat,Kai Zacharowski,Nicholas Obermüller,Katrin Rupprecht,Daniela Penzkofer,Carla Jennewein,Nguyen Tran,Bertram Scheller,Stefanie Dimmeler,Patrick Paulus +9 more
TL;DR: It is shown that Bβ15–42 alleviates early functional and morphological kidney damage as soon as 1 h and 3 h after ischemia and reperfusion, and may act as a potent renoprotective agent by preserving the endothelial and vascular integrity.