D
Darius Moradpour
Researcher at University of Lausanne
Publications - 304
Citations - 23849
Darius Moradpour is an academic researcher from University of Lausanne. The author has contributed to research in topics: Hepatitis C virus & Virus. The author has an hindex of 72, co-authored 287 publications receiving 22406 citations. Previous affiliations of Darius Moradpour include University of Freiburg & University Hospital of Lausanne.
Papers
More filters
Journal ArticleDOI
Effect of antiviral therapy on circulating cytokeratin-18 fragments in patients with chronic hepatitis C.
C. Sgier,B Müllhaupt,Tilman Gerlach,Darius Moradpour,Francesco Negro,P. J. Male,Markus H. Heim,Raffaele Malinverni,A. Cerny,Jean-François Dufour +9 more
TL;DR: Successful antiviral therapy results in a significant decrease in circulating levels of cytokeratin‐18 fragments arguing for a reduction in hepatocellular apoptosis after clearance of the HCV.
Journal ArticleDOI
Impact of genetic SLC28 transporter and ITPA variants on ribavirin serum level, hemoglobin drop and therapeutic response in patients with HCV infection
Monika Rau,Felix Stickel,Stefan Russmann,M. Weisskopf,Johannes Schmitt,Michael T. Dill,Jean-François Dufour,Darius Moradpour,David Semela,B Müllhaupt,Andreas Geier +10 more
Journal ArticleDOI
Characterization of Nonstructural Protein Membrane Anchor Deletion Mutants Expressed in the Context of the Hepatitis C Virus Polyprotein
Rainer Gosert,Rainer Gosert,Wiebke Jendrsczok,Jan Martin Berke,Jan Martin Berke,Volker Brass,Hubert E. Blum,Darius Moradpour,Darius Moradpour +8 more
TL;DR: The membrane anchor domains of nonstructural proteins are essential for incorporation of these proteins into the HCV replication complex while interactions among the cytosolic domains appear to be relatively weak.
Journal ArticleDOI
Elderly age is not a negative predictive factor for virological response to therapy with pegylated interferon-α and ribavirin in chronic hepatitis C virus patients.
Pascal Frei,Anna-Kathrin Leucht,Ulrike Held,Reto Kofmehl,Christine N. Manser,Johannes Schmitt,Joachim C. Mertens,Monika Rau,K Baur,Tilman Gerlach,Francesco Negro,Markus H. Heim,Darius Moradpour,Andreas Cerny,Jean-François Dufour,Beat Müllhaupt,Andreas Geier +16 more
TL;DR: Age is frequently discussed as negative host factor to achieve a sustained virological response to antiviral therapy of chronic hepatitis C, but elderly patients often show advanced fibrosis/cirrhosis as known negative predictive factor.
Journal ArticleDOI
Therapie der chronischen Hepatitis C
Darius Moradpour,H E Blum +1 more
TL;DR: Aufbauend auf einem verbesserten Verstandnis der molekularen Virologie and Pathogenese der Hepatitis C werden heute vielversprechende neue praventive and therapeutische Strategien exploriert.