D
Darius Moradpour
Researcher at University of Lausanne
Publications - 304
Citations - 23849
Darius Moradpour is an academic researcher from University of Lausanne. The author has contributed to research in topics: Hepatitis C virus & Virus. The author has an hindex of 72, co-authored 287 publications receiving 22406 citations. Previous affiliations of Darius Moradpour include University of Freiburg & University Hospital of Lausanne.
Papers
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Journal ArticleDOI
Viral pathogenesis of hepatocellular carcinoma.
Hubert E. Blum,Darius Moradpour +1 more
TL;DR: The role of HBV and HCV in the pathogenesis of H CC and strategies aimed at the prevention of HCC will be discussed.
Journal ArticleDOI
Serum ferritin levels are associated with a distinct phenotype of chronic hepatitis C poorly responding to pegylated interferon-alpha and ribavirin therapy.
Christian M. Lange,Zoltán Kutalik,Kenichi Morikawa,Stéphanie Bibert,Andreas Cerny,Günter Dollenmaier,Jean-François Dufour,Tilman Gerlach,Markus H. Heim,Raffaele Malinverni,Beat Müllhaupt,Francesco Negro,Darius Moradpour,Pierre-Yves Bochud +13 more
TL;DR: In patients with CHC, elevated serum ferritin levels are independently associated with advanced liver fibrosis, hepatic steatosis, and poor response to interferon‐alpha‐based therapy.
Journal ArticleDOI
Visualization of hepatitis E virus RNA and proteins in the human liver
Daniela Lenggenhager,Jérôme Gouttenoire,Mohsen Malehmir,Marion Bawohl,Hanna Honcharova-Biletska,Susanne Kreutzer,David Semela,Jörg Neuweiler,Sandra Hürlimann,Patrick Aepli,Montserrat Fraga,Roland Sahli,Luigi Terracciano,Laura Rubbia-Brandt,Beat Müllhaupt,Christine Sempoux,Darius Moradpour,Achim Weber +17 more
TL;DR: In this article, a panel of 12 different antibodies against HEV open reading frame (ORF) 1-3 proteins was evaluated for immunohistochemistry (IHC) and two probes for in situ hybridization (ISH) in formalin-fixed, paraffin-embedded (FFPE) HuH7 cells transfected with HEV ORF1-3 expression vectors.
Journal Article
Hepatitis C: an update.
TL;DR: Current concepts of the epidemiology, molecular virology, pathogenesis, natural history, diagnosis, therapy, and prevention of hepatitis C are reviewed.
Journal ArticleDOI
Expression of hepatitis C virus proteins does not interfere with major histocompatibility complex class I processing and presentation in vitro.
Darius Moradpour,Benno Grabscheid,Andreas Kammer,Gunter Schmidtke,Marcus Groettrup,Hubert E. Blum,Andreas Cerny +6 more
TL;DR: It is suggested that viral evasion of the host immune response does not involve interactions of HCV with MHC class I processing and presentation, and other mechanisms, such as interference with the interferon system, may be operative in HCV infection, leading to viral persistence.