D
Darius Moradpour
Researcher at University of Lausanne
Publications - 304
Citations - 23849
Darius Moradpour is an academic researcher from University of Lausanne. The author has contributed to research in topics: Hepatitis C virus & Virus. The author has an hindex of 72, co-authored 287 publications receiving 22406 citations. Previous affiliations of Darius Moradpour include University of Freiburg & University Hospital of Lausanne.
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Journal ArticleDOI
The Hepatitis C Virus RNA-Dependent RNA Polymerase Membrane Insertion Sequence Is a Transmembrane Segment
Natalia Ivashkina,Benno Wölk,Volker Lohmann,Ralf Bartenschlager,Hubert E. Blum,François Penin,Darius Moradpour +6 more
TL;DR: It is shown that the HCV RdRp C-terminal membrane insertion sequence traverses the phospholipid bilayer as a transmembrane segment, and an absolutely conserved GVG motif was not essential for membrane insertion but possibly provides a docking site for trans Membrane protein-protein interactions.
Journal ArticleDOI
Reduced IFNλ4 activity is associated with improved HCV clearance and reduced expression of interferon-stimulated genes
Ewa Terczyńska-Dyla,Stéphanie Bibert,Francois H.T. Duong,Francois H.T. Duong,Ilona Krol,Ilona Krol,Sanne Jørgensen,Emilie Collinet,Zoltán Kutalik,Zoltán Kutalik,Vincent Aubert,Andreas Cerny,Laurent Kaiser,Raffaele Malinverni,Alessandra Mangia,Darius Moradpour,Beat Müllhaupt,Francesco Negro,Rosanna Santoro,David Semela,Nasser Semmo,Markus H. Heim,Markus H. Heim,Pierre-Yves Bochud,Rune Hartmann +24 more
TL;DR: Evidence supporting a role for the active IFNλ4 protein as the driver of high hepatic ISG expression as well as the cause of poor HCV clearance is provided.
Journal ArticleDOI
Viral genotype-specific role of PNPLA3, PPARG, MTTP, and IL28B in hepatitis C virus-associated steatosis.
Tao Cai,Jean-François Dufour,Beat Muellhaupt,Tilman Gerlach,Markus H. Heim,Darius Moradpour,Andreas Cerny,Raffaele Malinverni,V. Kaddai,Murielle Bochud,Francesco Negro,Pierre-Yves Bochud +11 more
TL;DR: The rs738409 SNP in PNPLA3 is associated with an increased risk of steatosis in patients infected with HCV genotypes non-3, suggesting their interaction with viral factors.
Journal ArticleDOI
Management of viral hepatitis in patients with haematological malignancy and in patients undergoing haemopoietic stem cell transplantation: recommendations of the 5th European Conference on Infections in Leukaemia (ECIL-5)
Vincent Mallet,Vincent Mallet,Florian van Bömmel,Christopher Doerig,Sven Pischke,Olivier Hermine,Anna Locasciulli,Catherine Cordonnier,Thomas Berg,Darius Moradpour,Heiner Wedemeyer,Per Ljungman +11 more
TL;DR: The group recommends that all patients should be screened for hepatotropic viruses before haematological treatment and that patients or haemopoietic stem cell donors with markers of past or current viral hepatitis should be assessed by an expert.
Journal ArticleDOI
Molecular virology of hepatitis C virus (HCV): 2006 update.
TL;DR: A review of recent advances in the understanding of the molecular biology of hepatitis C virus (HCV) summarizes recent advances and discusses future research directions.