D
Darius Moradpour
Researcher at University of Lausanne
Publications - 304
Citations - 23849
Darius Moradpour is an academic researcher from University of Lausanne. The author has contributed to research in topics: Hepatitis C virus & Virus. The author has an hindex of 72, co-authored 287 publications receiving 22406 citations. Previous affiliations of Darius Moradpour include University of Freiburg & University Hospital of Lausanne.
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Journal ArticleDOI
An Analysis of the Benefit of Using HEV Genotype 3 Antigens in Detecting Anti-HEV IgG in a European Population
Annatina Schnegg,Philippe Bürgisser,Cyril Andre,Alain Kenfak-Foguena,Giorgia Canellini,Darius Moradpour,Florence Abravanel,Jacques Izopet,Matthias Cavassini,Katharine E A Darling +9 more
TL;DR: Although recomLine contains HEV genotype 3, it has lower sensitivity than Fortress in acute HEV infection and fails to identify infection as being due to this genotype in approximately 45% of patients.
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NMR structure and molecular dynamics of the in-plane membrane anchor of nonstructural protein 5A from bovine viral diarrhea virus.
Nicolas Sapay,Roland Montserret,Christophe Chipot,Volker Brass,Darius Moradpour,Gilbert Deléage,François Penin +6 more
TL;DR: Structural conservations point toward conserved roles of the N-terminal in-plane membrane anchors of NS5A in replication complex formation of HCV, BVDV, and other related viruses.
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Palmitoylation mediates membrane association of hepatitis E virus ORF3 protein and is required for infectious particle secretion.
Jérôme Gouttenoire,Angela Pollán,Laurence Abrami,Noémie Oechslin,Johann Mauron,Maxime Matter,Joël Oppliger,Dagmara Szkolnicka,Viet Loan Dao Thi,F. Gisou van der Goot,Darius Moradpour +10 more
TL;DR: It is shown that HEV ORF3 protein forms membrane-associated oligomers and palmitoylation determines the subcellular localization, membrane topology and function of HEV OrF3protein in the HEV life cycle.
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A genetic validation study reveals a role of vitamin D metabolism in the response to interferon-alfa-based therapy of chronic hepatitis C.
Christian M. Lange,Christian M. Lange,Stéphanie Bibert,Zoltán Kutalik,Philippe Bürgisser,Andreas Cerny,Jean-François Dufour,Andreas Geier,Tilman Gerlach,Markus H. Heim,Raffaele Malinverni,Francesco Negro,Stephan Regenass,Klaus Badenhoop,Jörg Bojunga,Christoph Sarrazin,Stefan Zeuzem,Tobias Müller,Thomas Berg,Pierre-Yves Bochud,Darius Moradpour +20 more
TL;DR: A role of bioactive vitamin D (1,25[OH]2D3, calcitriol) in the response to treatment of chronic hepatitis C is suggested, however, serum concentration of the calcitril precursor 25(OH)D3 is not a suitable predictor of treatment outcome.
Journal ArticleDOI
Cytotoxic T lymphocytes derived from patients with chronic hepatitis C virus infection kill bystander cells via Fas-FasL interaction.
Christel Gremion,Benno Grabscheid,Benno Wölk,Darius Moradpour,Jürg Reichen,Werner J. Pichler,Andreas Cerny +6 more
TL;DR: It is shown that endogenously processed HCV proteins are capable of inducing bystander killing and this data underscore the role of the Fas pathway in HCV-related liver injury and support the exploration of Fas-based treatment strategies for patients with chronic hepatitis C virus infection.