D
David E. Scherrer
Researcher at Washington University in St. Louis
Publications - 20
Citations - 1521
David E. Scherrer is an academic researcher from Washington University in St. Louis. The author has contributed to research in topics: Tissue factor & Oxysterol. The author has an hindex of 12, co-authored 20 publications receiving 1427 citations.
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Journal ArticleDOI
Molecular imaging and targeted drug delivery with a novel, ligand-directed paramagnetic nanoparticle technology.
Gregory M. Lanza,Dana R. Abendschein,Xin Yu,Patrick M. Winter,Kerry K. Karukstis,Michael J. Scott,Ralph W. Fuhrhop,David E. Scherrer,Samuel A. Wickline +8 more
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Tracking the Subcellular Fate of 20(S)-Hydroxycholesterol with Click Chemistry Reveals a Transport Pathway to the Golgi
Sara M. Peyrot,Sigrid Nachtergaele,Giovanni Luchetti,Laurel Mydock-McGrane,Hideji Fujiwara,David E. Scherrer,Andrew P. Jallouk,Paul H. Schlesinger,Daniel S. Ory,Douglas F. Covey,Rajat Rohatgi +10 more
TL;DR: In this article, the authors used click chemistry and fluorescence microscopy to image intracellular 20(S)-hydroxycholesterol with both high sensitivity and spatial resolution, and found that this oxysterol selectively accumulates in the Golgi membrane using a pathway sensitive to ATP levels, temperature, and lysosome function.
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99. Cholesterol oxidation products are sensitive and specific blood-based biomarkers for Niemann–Pick C1 disease
Daniel S. Ory,Forbes D. Porter,David E. Scherrer,Michael H. Lanier,Stephen J. Langmade,Vasumathi Molugu,Sarah E. Gale,Dana Olzeski,Rohini Sidhu,Christopher A. Wassif,Nicole M. Yanjanin,Jean E. Schaffer +11 more
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The peroxisome proliferator-activated receptor agonist pioglitazone and 5-lipoxygenase inhibitor zileuton have no effect on lung inflammation in healthy volunteers by positron emission tomography in a single-blind placebo-controlled cohort study
Delphine L. Chen,Howard J. Huang,Derek E. Byers,Adrian Shifren,Bryan G Belikoff,Jacquelyn T. Engle,Elizabeth Arentson,Debra Kemp,Sharon Phillips,David E. Scherrer,Hideji Fujiwara,Katherine J. Spayd,Frank J. Brooks,Richard A. Pierce,Mario Castro,Warren Isakow +15 more
TL;DR: Endotoxin-induced lung inflammation in humans is not responsive to pioglitazone or zileuton, highlighting the challenge in translating anti-inflammatory drug efficacy results from murine models to humans.
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Comparison of methods for local delivery of tissue factor pathway inhibitor to balloon-injured arteries in rabbits.
TL;DR: Sustained, marked retention of rTFPI delivered locally at the site of balloon-induced arterial injury appears to result from catheter-based systems that use passive diffusion at moderate pressure.