David E. Scherrer

TL;DR: The potential for abnormal thrombogenicity of balloon-injured arteries, as reflected by smooth muscle expression of tissue factor, was imaged using a novel, targeted, nanoparticulate ultrasonic contrast agent.

TL;DR: Quantification of the bile acid in dried blood spots provides the basis for a newborn screen for NPC that is ready for piloting in newborn screening programs and one of these bile acids should be evaluated for potential addition to neonatal screening programs.

TL;DR: Exposure to saturated fatty acids at concentrations that lead to endoplasmic reticulum membrane phospholipid remodeling inhibits oxysterol activity, and new insights are provided into the mechanism through which oxysterols regulate cellular cholesterol balance.

TL;DR: Islets from mice lacking Rpl13a snoRNAs demonstrated blunted oxidative stress responses, and these mice were protected against diabetogenic stimuli that cause oxidative stress damage to islets, illuminates a previously unrecognized role for sno RNAs in metabolic regulation.

TL;DR: Attenuation of procoagulant activity and tissue factor-mediated thrombin generation in response to injury may account for the promising results with rTFPI in the porcine angioplasty model.