D
David S. Wishart
Researcher at University of Alberta
Publications - 564
Citations - 93527
David S. Wishart is an academic researcher from University of Alberta. The author has contributed to research in topics: Metabolomics & Medicine. The author has an hindex of 108, co-authored 523 publications receiving 76652 citations. Previous affiliations of David S. Wishart include La Trobe University & International Agency for Research on Cancer.
Papers
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Journal ArticleDOI
Recombinant mouse prion protein alone or in combination with lipopolysaccharide alters expression of innate immunity genes in the colon of mice.
Elda Dervishi,Tran H. Lam,Suzana M. Dunn,Grzegorz Zwierzchowski,Fozia Saleem,David S. Wishart,Burim N. Ametaj +6 more
TL;DR: A potential role for moPrP as an endogenous ‘danger signal’ associated with activation of colon genes related to innate immunity and antibacterial responses is suggested.
Book ChapterDOI
Metabolomic Data Exploration and Analysis with the Human Metabolome Database.
TL;DR: This chapter covers three methods or protocols pertinent to using the HMDB: understanding the general layout of the HM DB; exploring the contents of a typical HMDB "MetaboCard"; and an example of how HMDB can be used in a metabolomics study on human glioblastoma.
Journal ArticleDOI
Serum metabolomics identifies metabolite panels that differentiate lame dairy cows from healthy ones
Guanshi Zhang,Guanshi Zhang,Grzegorz Zwierzchowski,Grzegorz Zwierzchowski,Rupasri Mandal,David S. Wishart,Burim N. Ametaj +6 more
TL;DR: Multiple metabolite and pathway alterations were identified in the serum of pre- lame, lame, and post-lame cows that through light into the pathobiology of the disease and that can be used as potential biomarker sets that can predict the risk of lameness in dairy cows.
Journal ArticleDOI
A Web Tool for Generating High Quality Machine-readable Biological Pathways
TL;DR: A protocol for the quick and easy creation of new pathways and the alteration of existing pathways is described, which has been successfully applied to generate over 2,000 pathway diagrams, which are now found in many online databases including HMDB, DrugBank, SMPDB, and ECMDB.
Book ChapterDOI
Design, synthesis and characterization of a water-soluble β-sheet peptide
David S. Wishart,Les H. Kondejewski,P. D. Semchuk,Cyril M. Kay,Robert S. Hodges,Brian D. Sykes +5 more
TL;DR: In this article, the authors describe methods that are developed to easily prepare a number of gramicidin S (β-sheet) analogs, using solid phase peptide synthesis and a simple but effective cyclization protocol.