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David S. Wishart
Researcher at University of Alberta
Publications - 564
Citations - 93527
David S. Wishart is an academic researcher from University of Alberta. The author has contributed to research in topics: Metabolomics & Medicine. The author has an hindex of 108, co-authored 523 publications receiving 76652 citations. Previous affiliations of David S. Wishart include La Trobe University & International Agency for Research on Cancer.
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Identification of a novel archaebacterial thioredoxin: determination of function through structure.
Sudeepa Bhattacharyya,Bahram Habibi-Nazhad,Godwin Amegbey,Carolyn M. Slupsky,Adelinda Yee,Cheryl H. Arrowsmith,David S. Wishart +6 more
TL;DR: NMR spectroscopy determined the solution structure and function of a previously unknown, conserved protein (MtH895) from the thermophilic archeon Methanobacterium thermoautotrophicum and identified a group of previously unknown proteins from several other archaebacteria that have significant sequence identity with MtH8 95.
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An improved method to detect correct protein folds using partial clustering.
Jianjun Zhou,David S. Wishart +1 more
TL;DR: The new method, named HS-Forest, avoids the computationally expensive task of clustering every decoy, yet still allows superior correct-fold selection, and should enable structure prediction researchers to work with larger decoy sets and significantly improve their ab initio structure prediction performance.
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Metabolomics Approach Reveals Altered Plasma Amino Acid and Sphingolipid Profiles Associated with Patholological State in Transition Dairy Cows
Dagnachew Hailemariam,Rupasri Mandal,Fozia Saleem,Suzanna M. Dunn,David S. Wishart,Burim N. Ametaj +5 more
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Sildenafil Therapy Normalizes the Aberrant Metabolomic Profile in the Comt(-/-) Mouse Model of Preeclampsia/Fetal Growth Restriction.
Joanna L. Stanley,Karolina Sulek,Irene J. Andersson,Sandra T. Davidge,Louise C. Kenny,Colin P. Sibley,Rupasri Mandal,David S. Wishart,David Broadhurst,Philip N. Baker +9 more
TL;DR: A potential new treatment, Sildenafil, is able to normalize the aberrant metabolomic profile in COMT−/− mice; as this treatment moves into clinical trials, this information may assist in assessing possible mechanisms of action.
Journal ArticleDOI
A method for the facile solid-phase synthesis of gramicidin S and its analogs
TL;DR: The presented method is simple, automatable, rapid (less than three days), high-yielding, requires no side-chain protection during cyclization, and appears to be generally applicable to the preparation of a variety of related head-to-tail cyclic peptides.