David Soong

TL;DR: In this paper, the genesis of genomic rearrangements, including abundant DNA translocations and deletions that arise in a highly interdependent manner, was modeled and shown to induce considerable genomic derangement over relatively few events in prostate cancer and other neoplasms, supporting a model of punctuated cancer evolution.

TL;DR: A proliferation screen of cell lines representing a number of tumor types indicated that small cell lung carcinoma (SCLC) is sensitive to LSD1 inhibition, and a subset of SCLC lines and primary samples that undergo growth inhibition in response to GSK2879552 exhibit DNA hypomethylation of a signature set of probes, suggesting this may be used as a predictive biomarker of activity.

TL;DR: Daratumumab plus bortezomib and dexamethasone demonstrated significant clinical activity across clinically relevant subgroups and provided the greatest benefit to patients treated at first relapse.

TL;DR: In relapsed/refractory multiple myeloma patients, daratumumab plus lenalidomide/dexamethasone continued to improve progression-free survival and deepen responses versus lenalidmide/ dexam ethasone regardless of number of prior lines of therapy.

TL;DR: It is demonstrated that oncogenic transcription factor overexpression is associated with global, reproducible, and functionally coherent changes in chromatin organization, as genomic alterations in other cancer types frequently give rise to aberrant transcription factor expression.