Michelle Cipicchio

TL;DR: In this paper, the genesis of genomic rearrangements, including abundant DNA translocations and deletions that arise in a highly interdependent manner, was modeled and shown to induce considerable genomic derangement over relatively few events in prostate cancer and other neoplasms, supporting a model of punctuated cancer evolution.

TL;DR: The findings highlight the complex genomic structure of mCRPC, nominate alterations that may inform prostate cancer treatment, and suggest that additional recurrent events in the non-coding m CRPC genome remain to be discovered.

TL;DR: A genome-wide map of large SV is constructed and 16 recurrent subclasses of complex SV (cxSV) are characterized, revealing that cxSV are larger and rarer than canonical SV and should be considered in genomic studies of human disease.

TL;DR: In this article, the authors combined a mathematical model of epidemic spread and empirically derived viral kinetics for SARS-CoV-2 infections to identify pooling designs that are robust to changes in prevalence and to ratify sensitivity losses against the time course of individual infections.

TL;DR: In this article , the authors introduce a massively parallel novel sequencing platform that combines an open flow cell design on a circular wafer with a large surface area and mostly natural nucleotides that allow optical end-point detection without reversible terminators.