D
David T. Breault
Researcher at Boston Children's Hospital
Publications - 117
Citations - 5335
David T. Breault is an academic researcher from Boston Children's Hospital. The author has contributed to research in topics: Stem cell & Biology. The author has an hindex of 30, co-authored 92 publications receiving 4040 citations. Previous affiliations of David T. Breault include University of Connecticut Health Center & Harvard University.
Papers
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Posted ContentDOI
β-catenin programs a tissue-specific epigenetic vulnerability in aggressive adrenocortical carcinoma
Dipika R. Mohan,Kleiton Silva Borges,Isabella Finco,Christopher R. LaPensee,Juilee Rege,April L. Solon,Donald W. Little,Tobias Else,Madson Q. Almeida,Derek Dang,James R. Haggerty-Skeans,April A. Apfelbaum,Michelle Vinco,Alda Wakamatsu,B. M. Mariani,Larissa Amorin,Ana Claudia Latronico,Berenice B. Mendonca,Maria Claudia Nogueira Zerbini,Elizabeth R. Lawlor,Ryoma Ohi,Richard J. Auchus,William E. Rainey,Suely Kazue Nagahashi Marie,Thomas J. Giordano,Sriram Venneti,Maria Candida Barisson Villares Fragoso,David T. Breault,Antonio M. Lerario,Gary D. Hammer +29 more
TL;DR: It is demonstrated that ACC differentiation is maintained by a balance between nuclear, tissue- specific β-catenin-containing complexes and the epigenome, illustrating how tissue-specific programs shape oncogene selection, surreptitiously encoding targetable therapeutic vulnerabilities.
Posted ContentDOI
Telomerase reverse transcriptase (TERT)-expressing cells mark a novel stem cell population in the adult mouse brain
Gabriel S Jensen,Ashleigh Beaulieu,Caroline d. Curtis,Joshua P Passarelli,Magdalena Blaszkiewicz,Seth Thomas,Trevor Morin,Jake W. Willows,Callie W. Greco,Ciara J. Brennan,Christopher Aniapam,Lydia Caron,Michele J. Alves,Matthew D. Lynes,Diana L. Carlone,David T. Breault,Kristy L. Townsend +16 more
TL;DR: For example, the authors showed that TERT+ cells in the adult mouse brain represent a novel population of multipotent stem cells that are localized to numerous classical neuro/gliogenic niches (including the ventricular-subventricular zone, hypothalamus, and olfactory bulb).
Journal ArticleDOI
Calcineurin regulates aldosterone production via dephosphorylation of NFATc4.
Mesut Berber,Sining Leng,Agnieszka Wengi,D. V. Winter,Alex Odermatt,F Beuschlein,Johannes Loffing,David T. Breault,David Penton +8 more
TL;DR: In this paper , it was shown that activation of Cn-NFATc4 signaling may explain low plasma aldosterone levels and hyperkalemia in patients treated with tacrolimus and provide novel molecular targets to treat primary aldosteronism.
Book ChapterDOI
Adrenal Zonation and Development
Emanuele Pignatti,Emanuele Pignatti,Sining Leng,Sining Leng,Diana L. Carlone,Diana L. Carlone,David T. Breault,David T. Breault +7 more
TL;DR: This chapter highlights the current knowledge of adrenocortical homeostasis and zonation in the adult, with an emphasis on the adrenal morphology and ultrastructure and the cellular mechanisms associated with direct cell fate conversion of zG to zF cells.
Journal ArticleDOI
False-positive very long-chain fatty acids in a case of autoimmune adrenal insufficiency
Jia Zhu,David T. Breault +1 more
TL;DR: A case of an 11-year-old boy with new-onset primary adrenal insufficiency due to autoimmune adrenalitis who was initially found to have elevated very long chain fatty acid (VLCFA) levels, suggestive of ALD, that normalized on repeat testing as mentioned in this paper.