D
David T. Breault
Researcher at Boston Children's Hospital
Publications - 117
Citations - 5335
David T. Breault is an academic researcher from Boston Children's Hospital. The author has contributed to research in topics: Stem cell & Biology. The author has an hindex of 30, co-authored 92 publications receiving 4040 citations. Previous affiliations of David T. Breault include University of Connecticut Health Center & Harvard University.
Papers
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Book ChapterDOI
Engineering the Niche for Intestinal Regeneration
Victor Hernandez-Gordillo,Abigail N. Koppes,Linda G. Griffith,David T. Breault,David T. Breault +4 more
TL;DR: There is an urgent need for the generation of intestinal tissues to serve as in-vitro models of intestinal development, function, and disease and to aid in replacement and repair of intestinal tissue in vivo.
Posted ContentDOI
Stiffness Regulates Intestinal Stem Cell Fate
Shijie He,Lei P,Wendy Kang,Priscilla Cheung,Priscilla Cheung,Tao Xu,Tao Xu,Miyeko D. Mana,Chan Young Park,He Wang,Shinya Imada,Russell Jo,Russell Jo,Wang J,Ruopeng Wang,Zhou Z,Chetal K,Stas E,Stas E,Mohad,Marianna Halasi,Marianna Halasi,Bruun-Rasmussen P,Ruslan I. Sadreyev,Irit Adini,Irit Adini,Richard A. Hodin,Yijing Zhang,David T. Breault,David T. Breault,Fernando D. Camargo,Fernando D. Camargo,Ömer H. Yilmaz,Jeffrey J. Fredberg,Nima Saeidi +34 more
TL;DR: Results demonstrate stiffness-dependent ISC reprograming wherein YAP nuclear translocation diminishes ISCs and Ki67+ progenitors and drives their differentiation towards goblet cells, suggesting stiffening as potential target to mitigate gut epithelial deterioration during IBD.
Journal ArticleDOI
Rosette morphology in zona glomerulosa formation and function.
TL;DR: A review of morphological features of the adrenal zona glomerulosa (zG), highlighting recent cellular and molecular discoveries that govern its formation is presented in this paper.
Posted ContentDOI
Species-specific enhancement of enterohemorrhagic E. Coli pathogenesis mediated by microbiome metabolites
Alessio Tovaglieri,Alexandra Sontheimer-Phelps,Alexandra Sontheimer-Phelps,Annelies Geirnaert,Rachelle Prantil-Baun,Diogo M. Camacho,David B. Chou,David B. Chou,Sasan Jalili-Firoozinezhad,Sasan Jalili-Firoozinezhad,Tomas de Wouters,Magdalena Kasendra,Michael Super,Mark Cartwright,Camilla A. Richmond,Camilla A. Richmond,David T. Breault,David T. Breault,Christophe Lacroix,Donald E. Ingber,Donald E. Ingber,Donald E. Ingber +21 more
TL;DR: The identified metabolites are sufficient to increase susceptibility to EHEC in the human Colon Chip model and they contribute to species-specific tolerance, which lays the foundation for therapeutic-modulation of microbe products in order to prevent and treat human bacterial infection.
Posted ContentDOI
Nutritional deficiency recapitulates intestinal injury associated with environmental enteric dysfunction in patient-derived Organ Chips
Amir Bein,Cicely W. Fadel,Ben Swenor,Wuji Cao,Rani K. Powers,Diogo M. Camacho,Arash Naziripour,Andrew W Parsons,Nina LoGrande,Sanjay Sharma,Seongmin Kim,Sasan Jalili Firoozinezhad,Jennifer Grant,David T. Breault,Junaid Iqbal,Asad Ali,Lee A. Denson,Sean R. Moore,Rachelle Prantil-Baun,Girija Goyal,Donald E. Ingber +20 more
TL;DR: In this article, the genotypic and phenotypic features of EED-associated intestinal injury can be reconstituted in a human intestine-on-a-chip (Intestine Chip) microfluidic culture device lined by organoid-derived intestinal epithelial cells from EED patients.