David T. Breault

TL;DR: This study investigates the expression pattern of a green fluorescent protein (GFP) reporter for mTert promoter activity (mTert-GFP), which may play a role in immune cell regulated repair in endometrial regeneration following a menses-like event.

TL;DR: The regulatory mechanisms underlying the quiescent state include factors essential for cell cycle control, stress response and survival pathways, developmental signalling pathways, and post-transcriptional modulation as discussed by the authors, and these regulatory mechanisms citing observations from the intestine and other self-renewing tissues.

TL;DR: Binding to FKBP8, which can be blocked by tacrolimus, is required for MLCK1 recruitment to intercellular junctions and downstream events leading to immune-mediated barrier loss.

TL;DR: Gene analysis showed increased expression of adrenal genes in female SCC-KO mice involved in cell cycle control, cell adhesion-extracellular matrix interaction and ligand receptor activity that could promote steroid production.

TL;DR: Stem cells and their niche have become much better characterized in recent years, and their radiation response can be elucidated in detail in experimental systems to help underpin both protection and therapeutic recommendations established from human epidemiological evidence.