D
David T. Breault
Researcher at Boston Children's Hospital
Publications - 117
Citations - 5335
David T. Breault is an academic researcher from Boston Children's Hospital. The author has contributed to research in topics: Stem cell & Biology. The author has an hindex of 30, co-authored 92 publications receiving 4040 citations. Previous affiliations of David T. Breault include University of Connecticut Health Center & Harvard University.
Papers
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Journal ArticleDOI
Corticotropin-releasing hormone deficiency increases allergen-induced airway inflammation in a mouse model of asthma
Eric S. Silverman,Eric S. Silverman,David T. Breault,Joseph Vallone,Srikanth Subramanian,Ayca D. Yilmaz,Sheeba Mathew,Venkat Subramaniam,Kelan G. Tantisira,Karel Pacak,Scott T. Weiss,Joseph A. Majzoub +11 more
TL;DR: It is concluded that CRH deficiency disrupts endogenous glucocorticoid production and enhances allergen-induced airway inflammation and lung mechanical dysfunction in mice, which could increase asthma severity in human subjects.
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The Circadian Clock Gene BMAL1 Coordinates Intestinal Regeneration.
TL;DR: The results show that a circadian rhythm in inflammation and regeneration occurs during the gastrointestinal syndrome, and the study and treatment of radiation-induced illnesses, and other gastrointestinal illnesses, should consider 24-hour timing in physiology and pathology.
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Angiotensin II induces coordinated calcium bursts in aldosterone-producing adrenal rosettes.
Nick A. Guagliardo,Peter M. Klein,Christina A. Gancayco,Adam C Lu,Sining Leng,Rany R. Makarem,Chelsea Cho,Craig G. Rusin,David T. Breault,Paula Q. Barrett,Mark P. Beenhakker +10 more
TL;DR: It is demonstrated that within the rosette, angiotensin II evokes periodic Ca v 3-dependent calcium events that form bursts that are stereotypic in form that define the calcium burst as the fundamental unit of zG layer activity evoked by angiotENSin II and highlight a novel role for the ro sette as a facilitator of cell communication.
Journal ArticleDOI
Characterization and Fate of Telomerase-expressing Epithelia during Kidney Repair
Jie Song,Suzanne Czerniak,Teresa Wang,Wendy Ying,Diana L. Carlone,David T. Breault,Benjamin D. Humphreys +6 more
TL;DR: The data suggest that cells expressing telomerase reverse transcriptase are not a progenitor-cell population, and they do not play a direct role in kidney repair.
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Primary Human Colonic Mucosal Barrier Crosstalk with Super Oxygen-Sensitive Faecalibacterium prausnitzii in Continuous Culture
Jianbo Zhang,Yu-Ja Huang,Jun Young Yoon,Jun Young Yoon,John Kemmitt,Charles V. Wright,Kirsten Schneider,Pierre Sphabmixay,Victor Hernandez-Gordillo,Steven J. Holcomb,Brij Bhushan,Gar Rohatgi,Kyle Benton,David Carpenter,Jemila C. Kester,George Eng,David T. Breault,Ömer H. Yilmaz,Mao Taketani,Christopher A. Voigt,David L. Trumper,Linda G. Griffith +21 more
TL;DR: This work investigated the effects of an abundant super oxygen-sensitive commensal anaerobe, Faecalibacterium prausnitzii, on a primary human mucosal barrier using a Gut-MIcrobiome (GuMI) physiome platform and identified elevated differentiation and hypoxia-responsive genes and pathways in the platform.