D
David T. Breault
Researcher at Boston Children's Hospital
Publications - 117
Citations - 5335
David T. Breault is an academic researcher from Boston Children's Hospital. The author has contributed to research in topics: Stem cell & Biology. The author has an hindex of 30, co-authored 92 publications receiving 4040 citations. Previous affiliations of David T. Breault include University of Connecticut Health Center & Harvard University.
Papers
More filters
Journal ArticleDOI
Letter David Breault and Alex Lichtler
Posted ContentDOI
WNT2B Deficiency Causes Increased Susceptibility to Colitis in Mice and Impairs Intestinal Epithelial Development in Humans
Amy E. O’Connell,Sathuwarman Raveenthiraraj,C. Adegboye,Wanshu Qi,Radhika S. Khetani,Akaljot Singh,Jasmine Jie Min. Lin,Jeff Goldsmith,Jay R. Thiagarajah,Diana L. Carlone,Jerrold R. Turner,Pankaj B. Agrawal,Michael A. Helmrath,David T. Breault +13 more
TL;DR: In this article , the impact of inflammatory challenge to the small intestine, using anti-CD3χ antibody, and to the colon, using dextran sodium sulfate (DSS), was assessed.
Loss of SUMO-specific protease 2 causes isolated glucocorticoid deficiency by blocking zonal transdifferentiation
Damien Dufour,T. Dumontet,Isabelle Sahut-Barnola,Meline Onzon,Eric Pussard,J. Wilmouth,J Olabe,C Lucas,Adrien Levasseur,Jean-Christophe Pointud,Florence Roucher-Boulez,Igor Tauveron,Guillaume Bossis,Edward T.H. Yeh,David T. Breault,Pierre Val,Anne-Marie Lefrançois-Martinez,Antoine Martinez +17 more
TL;DR: The findings suggest that the SUMO pathway is instrumental for adrenal zone homeostasis and stress response and shifts the balance between ACTH/PKA and WNT/β-catenin antagonistic pathways by repressing PKA catalytic activity and promoting ectopic β-Catenin activation.
Journal ArticleDOI
β-catenin-driven differentiation is a tissue-specific epigenetic vulnerability in adrenal cancer.
Dipika R. Mohan,Kleiton Silva Borges,Isabella Finco,Christopher R. LaPensee,Juilee Rege,April L. Solon,Donald W. Little,Tobias Else,Madson Q. Almeida,Derek Dang,James R. Haggerty-Skeans,April A. Apfelbaum,Michelle Vinco,Alda Wakamatsu,B. M. Mariani,Larissa Costa Amorim,Ana Claudia Latronico,Berenice B. Mendonca,Maria Claudia Nogueira Zerbini,Elizabeth R. Lawlor,Ryoma Ohi,Richard J. Auchus,William E. Rainey,Suely Kazue Nagahashi Marie,Thomas J. Giordano,Sriram Venneti,Maria Candida Barisson Villares Fragoso,David T. Breault,Antonio M. Lerario,Gary D. Hammer +29 more
TL;DR: In this article , the authors demonstrated that ACC differentiation is maintained by a balance between nuclear, tissue-specific β-catenin-containing complexes and the epigenome, and they demonstrated that the balance between αβ-catensin and the histone methyltransferase (EZH2) can be maintained by removing αβ catenin from chromatin.
Journal ArticleDOI
OR04-2 WNT2B Deficiency Results in Hyperreninemic Hypoaldosteronism in Humans and Mice
Svetlana Azova,Kaitlin J. Basham,David T. Breault,Gary D. Hammer,Christopher R. LaPensee,Amy E. O’Connell,Cláudio de Jesus Ribeiro,Kleiton Silva Borges,Adina F. Turcu,Donald Little III +9 more
TL;DR: In this paper , Wnt2b-null mice exhibit significantly increased plasma renin but normal aldosterone levels compared to wild-type controls, suggesting that WNT2b deficiency may cause hypofunction of the subcapsular zona glomerulosa (zG).