D
David T. Breault
Researcher at Boston Children's Hospital
Publications - 117
Citations - 5335
David T. Breault is an academic researcher from Boston Children's Hospital. The author has contributed to research in topics: Stem cell & Biology. The author has an hindex of 30, co-authored 92 publications receiving 4040 citations. Previous affiliations of David T. Breault include University of Connecticut Health Center & Harvard University.
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Journal ArticleDOI
Frizzled proteins are colonic epithelial receptors for C. difficile toxin B
Liang Tao,Jie Zhang,Jie Zhang,Paul Meraner,Alessio Tovaglieri,Xiaoqian Wu,Ralf Gerhard,Xinjun Zhang,William B. Stallcup,Ji Miao,Ji Miao,Xi He,Xi He,Julian G. Hurdle,David T. Breault,David T. Breault,Abraham L. Brass,Min Dong,Min Dong +18 more
TL;DR: FZDs are established as physiologically relevant receptors for TcdB in the colonic epithelium by carrying out CRISPR–Cas9-mediated genome-wide screens and identifying the members of the Wnt receptor frizzled family (FzDs) as TCDB receptors.
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Adrenocortical Zonation Results from Lineage Conversion of Differentiated Zona Glomerulosa Cells
Bethany D. Freedman,Bethany D. Freedman,Petra Bukovac Kempna,Petra Bukovac Kempna,Diana L. Carlone,Diana L. Carlone,Manasvi S. Shah,Manasvi S. Shah,Nick A. Guagliardo,Paula Q. Barrett,Celso E. Gomez-Sanchez,Joseph A. Majzoub,Joseph A. Majzoub,David T. Breault,David T. Breault +14 more
TL;DR: It is demonstrated that adrenocortical zonation and regeneration result from lineage conversion and may provide a paradigm for homeostatic cellular renewal in other tissues.
Journal ArticleDOI
Generation of mTert-GFP mice as a model to identify and study tissue progenitor cells
David T. Breault,Irene M. Min,Diana L. Carlone,Loredana G. Farilla,Dana M. Ambruzs,Daniel E. Henderson,Selma Algra,Robert K. Montgomery,Amy J. Wagers,Nicholas Hole +9 more
TL;DR: Together, these data provide direct evidence that mTert-GFP expression marks progenitor cells in blood and small intestine, validating these mice as a useful tool for the prospective identification, isolation, and functional characterization of progenitors/stem cells from multiple tissues.
Journal ArticleDOI
Human Colon-on-a-Chip Enables Continuous In Vitro Analysis of Colon Mucus Layer Accumulation and Physiology.
Alexandra Sontheimer-Phelps,David B. Chou,Alessio Tovaglieri,Thomas C. Ferrante,Taylor Duckworth,Cicely Fadel,Viktoras Frismantas,Arlene D. Sutherland,Sasan Jalili-Firoozinezhad,Magdalena Kasendra,Eric Stas,James C. Weaver,Camilla A. Richmond,Oren Levy,Rachelle Prantil-Baun,David T. Breault,Donald E. Ingber +16 more
TL;DR: This study shows the production of colonic mucus with a physiologically relevant bilayer structure in vitro, which can be analyzed in real time noninvasively and may offer a new preclinical tool to analyze the role of mucus in human intestinal homeostasis as well as diseases.
Journal ArticleDOI
Reprogrammed Stomach Tissue as a Renewable Source of Functional β Cells for Blood Glucose Regulation
Chaiyaboot Ariyachet,Alessio Tovaglieri,Guanjue Xiang,Jiaqi Lu,Manasvi S. Shah,Manasvi S. Shah,Camilla A. Richmond,Camilla A. Richmond,Catia S. Verbeke,Douglas A. Melton,Ben Z. Stanger,David J. Mooney,Ramesh A. Shivdasani,Shaun Mahony,Qing Xia,David T. Breault,David T. Breault,Qiao Zhou +17 more
TL;DR: It is shown that cells of the antral stomach have a previously unappreciated propensity for conversion into functional insulin-secreting cells, highlighting the potential for development of engineered stomach tissues as a renewable source of functional β cells for glycemic control.