David T. Breault

TL;DR: This document should serve as a "roadmap" for the development phases of comprehensive care centers (CCC) for individuals and families affected by CAH.

TL;DR: It is demonstrated that peripheral IGF-I/IGFBP3 controls CoSCs and their dysfunction in DE and Restoration of normoglycemia in patients with long-standing T1D via kidney-pancreas transplantation or in diabetic mice by treatment with an ecto-TMEM219 recombinant protein normalized circulating IGF-i/IGfBP3 levels and reestablished CoSC homeostasis.

TL;DR: The cells responsible for cardiac telomerase activity are identified, a significant diminution with age but a marked response to injury is demonstrated, and it is suggested that they represent a potential target for further investigation of cardiac regenerative potential.

TL;DR: It is demonstrated that adrenocortical-specific loss of ZNRF3, but not RNF43, results in adrenal hyperplasia that depends on Porcupine-mediated Wnt ligand secretion, and a Wnt/β-catenin signaling gradient in the adrenal cortex that is disrupted upon loss of z NRF3 is discovered.

TL;DR: In vivo and pathological relevance of TcdA–sGAGs interactions are demonstrated, and a potential therapeutic approach of protecting colonic tissues by blocking these interactions is revealed.