D
Davide Ruggero
Researcher at University of California, San Francisco
Publications - 118
Citations - 20361
Davide Ruggero is an academic researcher from University of California, San Francisco. The author has contributed to research in topics: Translation (biology) & EIF4E. The author has an hindex of 49, co-authored 111 publications receiving 17167 citations. Previous affiliations of Davide Ruggero include Fox Chase Cancer Center & University of Bologna.
Papers
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Journal ArticleDOI
ER stress–mediated autophagy promotes Myc-dependent transformation and tumor growth
Lori S. Hart,John T. Cunningham,Tatini Datta,Souvik Dey,Feven Tameire,Stacey L. Lehman,Bo Qiu,Haiyan Zhang,George J. Cerniglia,Meixia Bi,Yan Li,Yan Gao,Huayi Liu,Changhong Li,Amit Maity,Andrei Thomas-Tikhonenko,Alexander E. Perl,Albert C. Koong,Serge Y. Fuchs,J. Alan Diehl,Ian G. Mills,Davide Ruggero,Constantinos Koumenis +22 more
TL;DR: A role for UPR is established as an enhancer of c-Myc-induced transformation and suggest that UPR inhibition may be particularly effective against malignancies characterized by c- myc overexpression.
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Translational Control in Cancer Etiology
TL;DR: Current research will further enable us to explore novel mechanisms of translational control, functionally identify translationally controlled mRNA groups, and unravel their impact on cellular transformation and tumorigenesis.
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New frontiers in translational control of the cancer genome
Morgan L. Truitt,Davide Ruggero +1 more
TL;DR: The authors discuss emerging trends and exciting new discoveries that reveal how this translational circuitry contributes to specific aspects of tumorigenesis and cancer cell function, with a particular focus on recent insights into the role of translational control in the adaptive response to oncogenic stress conditions.
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Targeting the eIF4F translation initiation complex: a critical nexus for cancer development.
TL;DR: Identification of mRNAs particularly responsive to elevated eIF4F activity that typifies tumorigenesis underscores the critical role of eif4F in cancer and raises the exciting possibility of developing new-in-class small molecules targeting translation initiation as antineoplastic agents.
Journal ArticleDOI
Differential Requirements for eIF4E Dose in Normal Development and Cancer
Morgan L. Truitt,Crystal S. Conn,Zhen Shi,Xiaming Pang,Taku Tokuyasu,Alison Coady,Youngho Seo,Maria Barna,Davide Ruggero +8 more
TL;DR: It is demonstrated that the dose of eIF4E is essential for translating mRNAs that regulate reactive oxygen species, fueling transformation and cancer cell survival in vivo, and also for driving a translational program supporting tumorigenesis.