D
Davide Ruggero
Researcher at University of California, San Francisco
Publications - 118
Citations - 20361
Davide Ruggero is an academic researcher from University of California, San Francisco. The author has contributed to research in topics: Translation (biology) & EIF4E. The author has an hindex of 49, co-authored 111 publications receiving 17167 citations. Previous affiliations of Davide Ruggero include Fox Chase Cancer Center & University of Bologna.
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Journal ArticleDOI
Translation control of the immune checkpoint in cancer and its therapeutic targeting.
Yichen Xu,Mauro Poggio,Hyun Yong Jin,Zhen Shi,Craig M. Forester,Ying Wang,Ying Wang,Craig R. Stumpf,Lingru Xue,Emily Devericks,Lomon So,Hao G. Nguyen,Alice Griselin,John D. Gordan,Sarah E. Umetsu,Reich Siegfried Heinz,Stephen T. Worland,Saurabh Asthana,Maria Barna,Kevin R. Webster,John T. Cunningham,John T. Cunningham,Davide Ruggero +22 more
TL;DR: An in vivo mouse model of liver cancer is developed to study oncogene cooperation in immunosurveillance and reveals how immune-checkpoint proteins are manipulated by distinct oncogenes at the level of mRNA translation, which can be exploited for new immunotherapies.
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Deregulation of oncogene‐induced senescence and p53 translational control in X‐linked dyskeratosis congenita
TL;DR: Insight is provided into the basis for cancer susceptibility in human syndromes associated with ribosome dysfunction by showing that in DKC1m cells, p53 IRES‐dependent translation is impaired during oncogene‐induced senescence ex vivo and on DNA damage in vivo.
Journal ArticleDOI
Loss of Function of the Tumor Suppressor DKC1 Perturbs p27 Translation Control and Contributes to Pituitary Tumorigenesis
Cristian Bellodi,Olya Krasnykh,Nikesha Haynes,Marily Theodoropoulou,Guang Peng,Lorenzo Montanaro,Davide Ruggero +6 more
TL;DR: Findings show that genetic alterations in DKC1 could contribute to tumorigenesis associated with somatic cancers and establish a critical role for DKC 1 in tumor suppression, at least in part, through translational control of p27.
Journal ArticleDOI
ATF4 couples MYC-dependent translational activity to bioenergetic demands during tumour progression.
Feven Tameire,Ioannis I. Verginadis,Nektaria Maria Leli,Christine Polte,Crystal S. Conn,Rani Ojha,Carlo Salas Salinas,Frank Chinga,Alexandra M Monroy,Weixuan Fu,Paul P. Wang,Andrew V. Kossenkov,Jiangbin Ye,Ravi K. Amaravadi,Zoya Ignatova,Serge Y. Fuchs,J. Alan Diehl,Davide Ruggero,Constantinos Koumenis +18 more
TL;DR: An essential role is revealed for activating transcription factor 4 (ATF4) in survival following MYC activation, which establishes ATF4 as a cellular rheostat of MYC activity, which ensures that enhanced translation rates are compatible with survival and tumour progression.
Journal ArticleDOI
Oncogenic KRAS Regulates Amino Acid Homeostasis and Asparagine Biosynthesis via ATF4 and Alters Sensitivity to L-Asparaginase
Dana Gwinn,Dana Gwinn,Alexander Lee,Alexander Lee,Marcela Briones-Martin-del-Campo,Crystal S. Conn,David R. Simpson,David R. Simpson,Anna I Scott,Anthony Le,Tina M. Cowan,Davide Ruggero,E. Alejandro Sweet-Cordero,E. Alejandro Sweet-Cordero +13 more
TL;DR: Inhibition of AKT suppressed ASNS expression and, combined with depletion of extracellular asparagine, decreased tumor growth, and ASNS represents a promising therapeutic target in KRAS mutant NSCLC.