D
Davide Ruggero
Researcher at University of California, San Francisco
Publications - 118
Citations - 20361
Davide Ruggero is an academic researcher from University of California, San Francisco. The author has contributed to research in topics: Translation (biology) & EIF4E. The author has an hindex of 49, co-authored 111 publications receiving 17167 citations. Previous affiliations of Davide Ruggero include Fox Chase Cancer Center & University of Bologna.
Papers
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Journal ArticleDOI
ERα is an RNA-binding protein sustaining tumor cell survival and drug resistance.
Yichen Xu,Peiwei Huangyang,Ying Wang,Lingru Xue,Emily Devericks,Hao G. Nguyen,Xiuyan Yu,Juan A. Oses-Prieto,Alma L. Burlingame,Sohit Miglani,Hani Goodarzi,Davide Ruggero +11 more
TL;DR: In this article, the authors show that ERα RNA binding function is uncoupled from its activity to bind DNA and critical for breast cancer progression, and they also show ERα-associated mRNAs sustain cancer cell fitness and elicit cellular responses to stress.
Journal ArticleDOI
Enhanced MET translation and signaling sustains K-Ras driven proliferation under anchorage-independent growth conditions
Saori Fujita-Sato,Saori Fujita-Sato,Jacqueline Galeas,Morgan L. Truitt,Cameron Pitt,Anatoly Urisman,Sourav Bandyopadhyay,Davide Ruggero,Frank McCormick +8 more
TL;DR: The results indicate that enhanced Met expression and signaling is essential for anchorage-independent growth of K-Ras mutant cancer cells and suggests that pharmacological inhibitors of Met could be effective for K- Ras mutant tumor patients.
Patent
MTOR Modulators and Uses Thereof
Kevan M. Shokat,David A. Fruman,Pingda Ren,Troy Edward Wilson,Liansheng Li,Andrew C. Hsieh,Morris E. Feldman,Beth Apsel,Yi Liu,Christian Rommel,Katrina Chan,Davide Ruggero,David Pearce,Matthew R. Janes +13 more
TL;DR: In this paper, the authors provide methods and compositions for selective modulation of certain protein kinases, and especially mTor complexes, which are particularly useful in inhibiting mTor selectively for therapeutic applications.
Journal ArticleDOI
Parallel measurement of dynamic changes in translation rates in single cells
Kyuho Han,Ariel Jaimovich,Gautam Dey,Davide Ruggero,Oded Meyuhas,Nahum Sonenberg,Tobias Meyer +6 more
TL;DR: This study has developed a reporter system to measure real-time changes of translation rates in human or mouse individual cells by conjugating translation regulatory motifs to sequences encoding a nuclear targeted fluorescent protein and a controllable destabilization domain.
Journal ArticleDOI
Nuclear TARBP2 Drives Oncogenic Dysregulation of RNA Splicing and Decay.
Lisa Fish,Albertas Navickas,Bruce Culbertson,Yichen Xu,Hoang C.B. Nguyen,Steven Zhang,Myles Hochman,Ross A. Okimoto,Brian D. Dill,Henrik Molina,Hamed S. Najafabadi,Claudio R. Alarcón,Davide Ruggero,Hani Goodarzi +13 more
TL;DR: Using xenograft mouse models, it is found that TARBP2 affects tumor growth in the lung and that this is dependent on TarBP2-mediated destabilization of ABCA3 and FOXN3 and ZNF143 is established as an upstream regulator of TAR BP2 expression.