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Rani Ojha

Researcher at Post Graduate Institute of Medical Education and Research

Publications -  30
Citations -  8164

Rani Ojha is an academic researcher from Post Graduate Institute of Medical Education and Research. The author has contributed to research in topics: Autophagy & Programmed cell death. The author has an hindex of 16, co-authored 27 publications receiving 6263 citations. Previous affiliations of Rani Ojha include Stanford University & University of Pennsylvania.

Papers
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Journal ArticleDOI

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

Daniel J. Klionsky, +2522 more
- 21 Jan 2016 - 
TL;DR: In this paper, the authors present a set of guidelines for the selection and interpretation of methods for use by investigators who aim to examine macro-autophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes.
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Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)

Daniel J. Klionsky, +2983 more
- 08 Feb 2021 - 
TL;DR: In this article, the authors present a set of guidelines for investigators to select and interpret methods to examine autophagy and related processes, and for reviewers to provide realistic and reasonable critiques of reports that are focused on these processes.
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Targeting autophagy in cancer

Angelique Onorati, +3 more
- 15 Aug 2018 - 
TL;DR: Fundamental advances in the biology of autophagy are presented, approaches to targeting Autophagy, the preclinical rationale and clinical experience with hydroxychloroquine in cancer clinical trials, the potential role ofAutophagy in tumor immunity, and recent developments in next‐generation autophagic inhibitors that have clinical potential are presented.
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PPT1 promotes tumor growth and is the molecular target of chloroquine derivatives in cancer.

Vito W. Rebecca, +23 more
- 01 Feb 2019 - 
TL;DR: A novel dimeric CQ (DC661) capable of deacidifying the lysosome and inhibiting autophagy significantly better than hydroxychloroquine (HCQ) is reported, providing a strong rationale for targeting PPT1 in cancer.
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A unified approach to targeting the lysosome’s degradative and growth signaling roles

Vito W. Rebecca, +31 more
- 01 Nov 2017 - 
TL;DR: Chemical features of dimeric compounds that increase their lysosomal specificity, and a new molecular target for these compounds, reclassifying these compounds as targeted therapies are identified, providing a new strategy for cancer therapy.