D
Deborah Doody
Researcher at The Royal Marsden NHS Foundation Trust
Publications - 9
Citations - 437
Deborah Doody is an academic researcher from The Royal Marsden NHS Foundation Trust. The author has contributed to research in topics: Sex hormone-binding globulin & Breast cancer. The author has an hindex of 9, co-authored 9 publications receiving 407 citations.
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Journal ArticleDOI
Associations among Mammographic Density, Circulating Sex Hormones, and Polymorphisms in Sex Hormone Metabolism Genes in Postmenopausal Women
Ruth Warren,Jane Skinner,Evis Sala,Erika R. E. Denton,Mitch Dowsett,Elizabeth Folkerd,Catherine S. Healey,Alison M. Dunning,Deborah Doody,Bruce A.J. Ponder,Robert Luben,N. E. Day,Douglas F. Easton +12 more
TL;DR: It is concluded that mammographic density is largely independent of postmenopausal steroid hormone levels, indicating that these risk factors have, to a large extent, an independent etiology and suggesting that they may be independent predictors of breast cancer risk.
Journal ArticleDOI
Genome-Wide Association Study of Circulating Estradiol, Testosterone, and Sex Hormone-Binding Globulin in Postmenopausal Women
Jennifer Prescott,Jennifer Prescott,Deborah J. Thompson,Peter Kraft,Stephen J. Chanock,Tina Audley,Judith E. Brown,Jean Leyland,Elizabeth Folkerd,Deborah Doody,Susan E. Hankinson,Susan E. Hankinson,Susan E. Hankinson,David J. Hunter,David J. Hunter,Kevin B. Jacobs,Mitch Dowsett,David G. Cox,David G. Cox,Douglas F. Easton,Immaculata De Vivo,Immaculata De Vivo +21 more
TL;DR: The results suggest that the small magnitude of difference in hormone levels associated with common genetic variants is likely insufficient to detectably contribute to breast cancer risk.
Journal ArticleDOI
Phytoestrogen Exposure Is Associated with Circulating Sex Hormone Levels in Postmenopausal Women and Interact with ESR1 and NR1I2 Gene Variants
Yen-Ling Low,Alison M. Dunning,Mitch Dowsett,Elizabeth Folkerd,Deborah Doody,James I. Taylor,Amit Bhaniani,Robert Luben,Kay-Tee Khaw,Nicholas J. Wareham,Sheila Bingham +10 more
TL;DR: It is concluded that phytoestrogens modulate sex hormone and SHBG levels in postmenopausal women and interact with gene variants involved in estrogen signaling and may explain the conflicting literature on the hormonal effects of phy toestrogens.
Journal ArticleDOI
CYP19A1 fine-mapping and Mendelian randomization: estradiol is causal for endometrial cancer
Deborah J. Thompson,Tracy A. O'Mara,Dylan M. Glubb,Jodie N. Painter,Timothy H.T. Cheng,Elizabeth Folkerd,Deborah Doody,Joe Dennis,Penelope M. Webb,Maggie Gorman,Lynn Martin,Shirley Hodgson,Kyriaki Michailidou,Jonathan Tyrer,Mel Maranian,Per Hall,Kamila Czene,Hatef Darabi,Jingmei Li,Peter A. Fasching,Alexander Hein,Matthias W. Beckmann,Arif B. Ekici,Thilo Dörk,Peter Hillemanns,Matthias Dürst,Ingo B. Runnebaum,Hui Zhao,Jeroen Depreeuw,Stefanie Schrauwen,Frédéric Amant,Ellen L. Goode,Brooke L. Fridley,Sean C. Dowdy,Stacey J. Winham,Helga B. Salvesen,Jone Trovik,Tormund S. Njolstad,Henrica M.J. Werner,Katie Ashton,Tony Proietto,Geoffrey Otton,Luis G. Carvajal-Carmona,Emma Tham,Tao Liu,Miriam Mints,Rodney J. Scott,Mark McEvoy,John Attia,Elizabeth G. Holliday,Grant W. Montgomery,Nicholas G. Martin,Dale R. Nyholt,Anjali K. Henders,John L. Hopper,Nadia Traficante,Matthias Ruebner,Anthony J. Swerdlow,Barbara Burwinkel,Hermann Brenner,Alfons Meindl,Hiltrud Brauch,Annika Lindblom,Diether Lambrechts,Jenny Chang-Claude,Fergus J. Couch,Graham G. Giles,Vessela N. Kristensen,Angela Cox,Manjeet K. Bolla,Qin Wang,Stig E. Bojesen,Mitul Shah,Robert Luben,Kay-Tee Khaw,Paul D.P. Pharoah,Alison M. Dunning,Ian Tomlinson,Mitch Dowsett,Douglas F. Easton,Amanda B. Spurdle +80 more
TL;DR: The first genome wide-significant association between endometrial cancer and a CYP19A1 SNP (rs727479 in intron 2, P=4.8x10(-11) was reported in this article.
Journal ArticleDOI
Polymorphisms in the CYP19 gene may affect the positive correlations between serum and urine phytoestrogen metabolites and plasma androgen concentrations in men
Yen-Ling Low,James I. Taylor,Philip B. Grace,Philip B. Grace,Mitch Dowsett,Elizabeth Folkerd,Deborah Doody,Alison M. Dunning,Serena Scollen,Angela A. Mulligan,Ailsa A Welch,Robert Luben,Kay-Tee Khaw,Nicholas E. Day,Nicholas J. Wareham,Sheila Bingham +15 more
TL;DR: Enterolactone and equol are positively associated with plasma androgen concentrations, and interactions with CYP19 gene may be involved, in this first study on phytoestrogen-gene associations in men.