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Debra L Compton
Researcher at Regeneron
Publications - 7
Citations - 9589
Debra L Compton is an academic researcher from Regeneron. The author has contributed to research in topics: Receptor tyrosine kinase & Vascular endothelial growth factor A. The author has an hindex of 7, co-authored 7 publications receiving 9273 citations. Previous affiliations of Debra L Compton include Beth Israel Deaconess Medical Center.
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Journal ArticleDOI
Angiopoietin-2, a Natural Antagonist for Tie2 That Disrupts in vivo Angiogenesis
Maisonpierre Peter C,Chitra Suri,Pamela F. Jones,Sona Bartunkova,Stanley J. Wiegand,Czeslaw Radziejewski,Debra L Compton,Joyce Mcclain,Aldrich Thomas H,Nick Papadopoulos,Thomas J. Daly,Samuel Davis,Thomas N. Sato,George D. Yancopoulos +13 more
TL;DR: The discovery of a negative regulator acting on Tie2 emphasizes the need for exquisite regulation of this angiogenic receptor system.
Journal ArticleDOI
Vessel Cooption, Regression, and Growth in Tumors Mediated by Angiopoietins and VEGF
Jocelyn Holash,Maisonpierre Peter C,Debra L Compton,Patricia Boland,C. R. Alexander,David Zagzag,George D. Yancopoulos,Stanley J. Wiegand +7 more
TL;DR: Evidence is presented here that a subset of tumors instead initially grows by coopting existing host vessels and regresses, leading to a secondarily avascular tumor and massive tumor cell loss.
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Isolation of Angiopoietin-1, a Ligand for the TIE2 Receptor, by Secretion-Trap Expression Cloning
Samuel Davis,Aldrich Thomas H,Pamela F. Jones,Ann Acheson,Debra L Compton,Vivek Jain,Terence E Ryan,Joanne Bruno,Czeslaw Radziejewski,Maisonpierre Peter C,George D. Yancopoulos +10 more
TL;DR: The identification of a secreted ligand for TIE2, termed Angiopoietin-1, is reported using a novel expression cloning technique that involves intracellular trapping and detection of the ligand in COS cells.
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The Receptor Tyrosine Kinase MuSK Is Required for Neuromuscular Junction Formation In Vivo
Thomas M. DeChiara,David C. Bowen,David M. Valenzuela,Mary V. Simmons,William Poueymirou,Susan Thomas,Erika Kinetz,Debra L Compton,Rojas Eduardo A,John S. Park,Cynthia L. Smith,Peter S. DiStefano,David J. Glass,Steven J. Burden,George D. Yancopoulos +14 more
TL;DR: It is indicated that MuSK responds to a critical nerve-derived signal (agrin), and in turn activates signaling cascades responsible for all aspects of synapse formation, including organization of the postsynaptic membrane, synapse-specific transcription, and presynaptic differentiation.
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Receptor tyrosine kinase specific for the skeletal muscle lineage: Expression in embryonic muscle, at the neuromuscular junction, and after injury
David M. Valenzuela,Trevor Stitt,Peter S. DiStefano,Rojas Eduardo A,Karen Mattsson,Debra L Compton,Lorna Nunez,John S. Park,Jennifer L. Stark,David R. Gies,Susan Thomas,Michelle M. Le Beau,Anthony A. Fernald,Neal G. Copeland,Nancy A. Jenkins,Steven J. Burden,David J. Glass,George D. Yancopoulos +17 more
TL;DR: Identification of MuSK introduces a novel receptor-factor system that seems sure to play an important and selective role in many aspects of skeletal muscle development and function.