D
Denisa Ilencikova
Researcher at Comenius University in Bratislava
Publications - 34
Citations - 1056
Denisa Ilencikova is an academic researcher from Comenius University in Bratislava. The author has contributed to research in topics: Germline mutation & Cancer. The author has an hindex of 15, co-authored 34 publications receiving 877 citations. Previous affiliations of Denisa Ilencikova include Boston Children's Hospital.
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Journal ArticleDOI
Diagnostic criteria for constitutional mismatch repair deficiency syndrome: suggestions of the European consortium ‘Care for CMMRD’ (C4CMMRD)
Katharina Wimmer,Christian P. Kratz,Hans F. A. Vasen,Olivier Caron,Chrystelle Colas,Chrystelle Colas,Natacha Entz-Werle,Anne-Marie Gerdes,Yael Goldberg,Denisa Ilencikova,Martine Muleris,Martine Muleris,Alex Duval,Alex Duval,Noémie Lavoine,Clara Ruiz-Ponte,Irene Slavc,Brigit Burkhardt,Laurence Brugières +18 more
TL;DR: It is expected that application of the suggested strategy for CMMRD diagnosis will increase the number of patients being identified at the time when they develop their first tumour, allowing adjustment of the treatment modalities, offering surveillance strategies for second malignancies and appropriate counselling of the entire family.
Journal ArticleDOI
Guidelines for surveillance of individuals with constitutional mismatch repair-deficiency proposed by the European Consortium "Care for CMMR-D" (C4CMMR-D)
Hans F. A. Vasen,Zeinab Ghorbanoghli,Franck Bourdeaut,Odile Cabaret,Olivier Caron,Alex Duval,Natacha Entz-Werle,Yael Goldberg,Denisa Ilencikova,Denisa Ilencikova,Christian P. Kratz,Noémie Lavoine,Jan Loeffen,Fred H. Menko,Martine Muleris,G Sebille,Chrystelle Colas,Birgit Burkhardt,Laurence Brugières,Katharina Wimmer +19 more
TL;DR: The evaluation showed that surveillance for CRC is the only part of the programme that largely complies with the WHO criteria and it is questionable whether surveillance for haematological malignancies improves the already favourable outcome for patients with these tumours.
Journal ArticleDOI
Diagnosis of Constitutional Mismatch Repair-Deficiency Syndrome Based on Microsatellite Instability and Lymphocyte Tolerance to Methylating Agents
Sahra Bodo,Chrystelle Colas,Olivier Buhard,Ada Collura,Julie Tinat,Noémie Lavoine,Agathe Guilloux,Alexandra Chalastanis,Philippe Lafitte,Florence Coulet,Marie-Pierre Buisine,Denisa Ilencikova,Clara Ruiz-Ponte,Miriam Kinzel,Sophie Grandjouan,Hilde Brems,Sophie Lejeune,Hélène Blanché,Qing Wang,Olivier Caron,Odile Cabaret,Magali Svrcek,Dominique Vidaud,Béatrice Parfait,Alain Verloes,Ulrich J. Knappe,Florent Soubrier,Isabelle Mortemousque,Alexander Leis,Jessie Auclair-Perrossier,Thierry Frebourg,Jean-François Fléjou,Natacha Entz-Werle,Julie Leclerc,David Malka,Odile Cohen-Haguenauer,Yael Goldberg,Anne-Marie Gerdes,Faten Fedhila,Michèle Mathieu-Dramard,Richard Hamelin,Badre Wafaa,Marion Gauthier-Villars,Franck Bourdeaut,Eamonn Sheridan,Hans F. A. Vasen,Laurence Brugières,Katharina Wimmer,Martine Muleris,Alex Duval +49 more
TL;DR: The presence of MSI and tolerance to methylation in LCs identified patients with CMMRD with 100% sensitivity and specificity and could be used in diagnosis of patients.
Journal ArticleDOI
Human MSH6 Deficiency Is Associated with Impaired Antibody Maturation
Pauline Gardès,Monique Forveille,Marie-Alexandra Alyanakian,Pierre Aucouturier,Pierre Aucouturier,Denisa Ilencikova,Dominique Leroux,Nils Rahner,Fabienne Mazerolles,Fabienne Mazerolles,Alain Fischer,Alain Fischer,Sven Kracker,Sven Kracker,Anne Durandy,Anne Durandy +15 more
TL;DR: The data suggest that in human CSR, MSH6 is involved in both the induction and repair of DNA double-strand breaks in switch regions, and the skewed SHM pattern strongly suggests that MSH 6 is involvement in the human SHM process.
Journal ArticleDOI
High Yield of Pathogenic Germline Mutations Causative or Likely Causative of the Cancer Phenotype in Selected Children with Cancer
Illja J. Diets,Esmé Waanders,Marjolijn J. L. Ligtenberg,Diede A G van Bladel,Eveline J. Kamping,Peter M. Hoogerbrugge,Saskia M. J. Hopman,Maran J. W. Olderode-Berends,Erica H. Gerkes,David A. Koolen,Carlo Marcelis,Gijs W. E. Santen,Martine J. van Belzen,Dylan A. Mordaunt,Lesley M McGregor,Elizabeth Thompson,Antonis Kattamis,Agata Pastorczak,Wojciech Młynarski,Denisa Ilencikova,Anneke Vulto van Silfhout,Thatjana Gardeitchik,Eveline S. J. M. de Bont,Jan Loeffen,Anja Wagner,Arjen R. Mensenkamp,Roland P. Kuiper,Nicoline Hoogerbrugge,Marjolijn C.J. Jongmans +28 more
TL;DR: The study shows the added value of sequencing beyond a cancer gene panel in selected patients, to recognize childhood cancer predisposition.