D
Dennis Bruemmer
Researcher at University of Pittsburgh
Publications - 93
Citations - 5989
Dennis Bruemmer is an academic researcher from University of Pittsburgh. The author has contributed to research in topics: Receptor & Vascular smooth muscle. The author has an hindex of 39, co-authored 91 publications receiving 5295 citations. Previous affiliations of Dennis Bruemmer include Baylor College of Medicine & University of Kentucky.
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Journal ArticleDOI
A new glucagon and GLP-1 co-agonist eliminates obesity in rodents
Jonathan Day,Nickki Ottaway,James Patterson,Vasily M. Gelfanov,David L. Smiley,Jas Gidda,Hannes M. Findeisen,Dennis Bruemmer,Daniel J. Drucker,Nilika Chaudhary,Jenna Holland,Jazzminn Hembree,William Abplanalp,Erin Grant,Jennifer Ruehl,Hilary Wilson,Henriette Kirchner,Sarah Kathleen Haas Lockie,Susanna M. Hofmann,Stephen C. Woods,Rubén Nogueiras,Paul T. Pfluger,Diego Perez-Tilve,Richard D. DiMarchi,Matthias H. Tschöp +24 more
TL;DR: Preclinical studies indicate that when full GLP-1 agonism is augmented with an appropriate degree of glucagon receptor activation, body fat reduction can be substantially enhanced without any overt adverse effects.
Journal ArticleDOI
Unimolecular Dual Incretins Maximize Metabolic Benefits in Rodents, Monkeys, and Humans
Brian Finan,Brian Finan,Tao Ma,Nickki Ottaway,Timo D. Müller,Kirk M. Habegger,Kristy M. Heppner,Henriette Kirchner,Jenna Holland,Jazzminn Hembree,Christine Raver,Sarah Kathleen Haas Lockie,David L. Smiley,Vasily M. Gelfanov,Bin Yang,Susanna M. Hofmann,Dennis Bruemmer,Daniel J. Drucker,Paul T. Pfluger,Paul T. Pfluger,Diego Perez-Tilve,Jaswant Gidda,Louis Vignati,Lianshan Zhang,Jonathan Hauptman,Michele Lau,Mathieu Brecheisen,Sabine Uhles,William Riboulet,Emmanuelle Hainaut,Elena Sebokova,Karin Conde-Knape,Anish Konkar,Richard D. DiMarchi,Matthias H. Tschöp,Matthias H. Tschöp +35 more
TL;DR: This discovery and validation of a balanced and high-potency dual incretin agonist enables a more physiological approach to management of diseases associated with impaired glucose tolerance and represents a new class of drug candidates for the treatment of metabolic diseases.
Journal ArticleDOI
Osteopontin Mediates Obesity-Induced Adipose Tissue Macrophage Infiltration and Insulin Resistance in Mice
Takashi Nomiyama,Diego Perez-Tilve,Daisuke Ogawa,Florence Gizard,Yue Zhao,Elizabeth B. Heywood,Karrie L. Jones,Ryuzo Kawamori,Lisa A. Cassis,Matthias H. Tschöp,Dennis Bruemmer +10 more
TL;DR: It is suggested that osteopontin may play a key role in linking obesity to the development of insulin resistance by promoting inflammation and the accumulation of macrophages in adipose tissue.
Journal ArticleDOI
Osteopontin: A novel regulator at the cross roads of inflammation, obesity and diabetes.
TL;DR: Recent findings on the role of osteopontin in metabolic disorders, particularly focusing on diabetes and obesity are summarized.
Journal ArticleDOI
Angiotensin II-accelerated atherosclerosis and aneurysm formation is attenuated in osteopontin-deficient mice
Dennis Bruemmer,Alan R. Collins,Grace Noh,Wei Wang,Mary C. Territo,Sarah Arias-Magallona,Michael C. Fishbein,Florian Blaschke,Ulrich Kintscher,Kristof Graf,Ronald E. Law,Willa A. Hsueh +11 more
TL;DR: An important role is suggested for leukocyte-derived OPN in mediating Ang II-accelerated atherosclerosis and aneurysm formation.