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Open AccessJournal ArticleDOI

GATA2 deficiency: a protean disorder of hematopoiesis, lymphatics and immunity

Michael A. Spinner, +24 more
- 06 Feb 2014 - 
- Vol. 123, Iss: 6, pp 809-821
TLDR
GATA2 deficiency unites susceptibility to MDS/AML, immunodeficiency, pulmonary disease, and vascular/lymphatic dysfunction, and monocytopenia, B, NK, and CD4 lymphocy topenia correlated with the presence of disease.
About: 
This article is published in Blood.The article was published on 2014-02-06 and is currently open access. It has received 554 citations till now. The article focuses on the topics: Monocytopenia & MonoMAC.

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Citations
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Journal ArticleDOI

NK cells and cancer: you can teach innate cells new tricks

Maelig G. Morvan, +1 more
- 01 Jan 2016 - 
TL;DR: Evidence for the role of NK cells in immune surveillance against cancer and new therapeutic approaches for targetingNK cells in the treatment of cancer are reviewed.
Journal ArticleDOI

NK cells for cancer immunotherapy.

Noriko Shimasaki, +2 more
- 06 Jan 2020 - 
TL;DR: New approaches to activate NK cells, increase their proliferation in vivo and increase their capacity to recognize tumour cells are discussed.
Journal ArticleDOI

A Single Oncogenic Enhancer Rearrangement Causes Concomitant EVI1 and GATA2 Deregulation in Leukemia

Stefan Gröschel, +21 more
- 10 Apr 2014 - 
TL;DR: The data show that structural rearrangements involving the chromosomal repositioning of a single enhancer can cause deregulation of two unrelated distal genes, with cancer as the outcome.

Iconographies supplémentaires de l'article : Practice parameter for the diagnosis and management of primary immunodeficiency

Francisco A. Bonilla, +27 more
TL;DR: This document incorporated the efforts of many participants, and no single individual, including those who served on the Joint Task Force, is authorized to provide an official AAAAI or ACAAI interpretation of these practice parameters.
Journal ArticleDOI

Mendelian susceptibility to mycobacterial disease: genetic, immunological, and clinical features of inborn errors of IFN-γ immunity

Jacinta Bustamante, +5 more
- 01 Dec 2014 - 
TL;DR: The genetic, immunological, and clinical features of patients with inborn errors of IFN-γ-dependent immunity, as well as the high level of allelic heterogeneity, are reviewed.
References
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Book

WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues

Stevens H. Swerdlow...
TL;DR: Thank you very much for reading who classification of tumours of haematopoietic and lymphoid tissues, and maybe you have knowledge that, people have look hundreds of times for their chosen readings like this, but end up in malicious downloads.
Journal ArticleDOI

A method and server for predicting damaging missense mutations.

Ivan Adzhubei, +7 more
- 01 Apr 2010 - 
TL;DR: A new method and the corresponding software tool, PolyPhen-2, which is different from the early tool polyPhen1 in the set of predictive features, alignment pipeline, and the method of classification is presented and performance, as presented by its receiver operating characteristic curves, was consistently superior.
Journal ArticleDOI

Comprehensive molecular portraits of human breast tumours

Daniel C. Koboldt, +355 more
- 04 Oct 2012 - 
TL;DR: The ability to integrate information across platforms provided key insights into previously defined gene expression subtypes and demonstrated the existence of four main breast cancer classes when combining data from five platforms, each of which shows significant molecular heterogeneity.
Journal ArticleDOI

An early haematopoietic defect in mice lacking the transcription factor GATA-2.

Fong-Ying Tsai, +9 more
- 15 Sep 1994 - 
TL;DR: It is demonstrated that the transcription factor GATA-2 plays a critical role in haematopoiesis, particularly of an adult type, and proposed that it regulates genes controlling growth factor responsiveness or the proliferative capacity of early haem atopoietic cells.
Journal ArticleDOI

Erythroid differentiation in chimaeric mice blocked by a targeted mutation in the gene for transcription factor GATA-1

Larysa Pevny, +7 more
- 17 Jan 1991 - 
TL;DR: The disruption of the X-linked GATA-1 gene by homologous recombination in a male (XY) murine embryonic stem cell line and testing the Gata-1-deficient cells for their ability to contribute to different tissues in chimaeric mice demonstrates that GATA, the zinc-finger transcription factor, is required for the normal differentiation of erythroid cells, and that other GATAS cannot compensate for its absence.
Related Papers (5)

Mutations in GATA2 are associated with the autosomal dominant and sporadic monocytopenia and mycobacterial infection (MonoMAC) syndrome

Amy P. Hsu, +25 more
- 08 Sep 2011 - 

Heritable GATA2 mutations associated with familial myelodysplastic syndrome and acute myeloid leukemia

Christopher N. Hahn, +35 more
- 01 Oct 2011 - 

Mutations in GATA2 cause primary lymphedema associated with a predisposition to acute myeloid leukemia (Emberger syndrome)

Pia Ostergaard, +19 more
- 01 Oct 2011 - 

Exome sequencing identifies GATA-2 mutation as the cause of dendritic cell, monocyte, B and NK lymphoid deficiency

Rachel E. Dickinson, +23 more
- 08 Sep 2011 - 

Prevalence, clinical characteristics, and prognosis of GATA2-related myelodysplastic syndromes in children and adolescents.

Marcin W. Wlodarski, +35 more
- 17 Mar 2016 -