D
Dennis Drayna
Researcher at National Institutes of Health
Publications - 48
Citations - 8835
Dennis Drayna is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Locus (genetics) & Gene. The author has an hindex of 29, co-authored 46 publications receiving 8486 citations. Previous affiliations of Dennis Drayna include Genentech & Howard Hughes Medical Institute.
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Journal ArticleDOI
A novel MHC class I–like gene is mutated in patients with hereditary haemochromatosis
John N. Feder,Andreas Gnirke,Winston Thomas,Zenta Tsuchihashi,David A. Ruddy,A. Basava,F. Dormishian,R. Domingo,Michael C. Ellis,A. Fullan,L.M. Hinton,Norman Jones,B.E. Kimmel,Gregory S. Kronmal,Peter M. San Francisco Lauer,V.K. Lee,Deborah B. Loeb,Felipa A. Mapa,Erin E. McClelland,Nicole C. Meyer,Gabe Mintier,N. Moeller,T. E. Moore,E. Morikang,Cynthia E. Prass,Leah Quintana,Steven M. Starnes,Randall C. Schatzman,K.J. Brunke,Dennis Drayna,Neil Risch,Bruce R. Bacon,Roger K. Wolff +32 more
TL;DR: Using linkage-disequilibrium and full haplotype analysis, this paper identified a 250-kilobase region more than 3 megabases telomeric of the major histocompatibility complex (MHC) that is identical-by-descent in 85% of patient chromosomes.
Journal ArticleDOI
Positional cloning of the human quantitative trait locus underlying taste sensitivity to phenylthiocarbamide
TL;DR: A small region on chromosome 7q that shows strong linkage disequilibrium between single-nucleotide polymorphism (SNP) markers and PTC taste sensitivity in unrelated subjects and a single gene that encodes a member of the TAS2R bitter taste receptor family is identified.
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The molecular basis of individual differences in phenylthiocarbamide and propylthiouracil bitterness perception.
Bernd Bufe,Paul A. S. Breslin,Christian Kuhn,Danielle R. Reed,Christopher D. Tharp,Jay Patrick Slack,Un Kyung Kim,Dennis Drayna,Wolfgang Meyerhof +8 more
TL;DR: Individual psychogenomic pathways for bitter taste are mapped by testing people with a variety of psychophysical tasks and linking their individual perceptions of the compounds PTC and propylthiouracil to the in vitro responses of their TAS2R38 receptor variants.
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Isolation, molecular cloning, and partial characterization of a novel carboxypeptidase B from human plasma.
TL;DR: It is proposed that the Mr 60,000 plasminogen-binding protein isolated here is a novel human plasma carboxypeptidase B and that it be designated pCPB.
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Cloning and sequencing of human cholesteryl ester transfer protein cDNA
Dennis Drayna,Alisha Stephens Jarnagin,John W. McLean,William J. Henzel,William J. Kohr,Christopher Fielding,Richard M. Lawn +6 more
TL;DR: The preparation of a highly active CETP of M r 74,000 purified about 100,000-fold from human plasma may represent the functional component of earlier preparations, and complementary DNA derived from human liver DNA has been cloned and sequenced and the cloned DNA used to detect CETP messenger RNA in a number of human tissues.