D
Derek J. Smith
Researcher at University of Cambridge
Publications - 135
Citations - 18468
Derek J. Smith is an academic researcher from University of Cambridge. The author has contributed to research in topics: Virus & Influenza A virus. The author has an hindex of 54, co-authored 121 publications receiving 16430 citations. Previous affiliations of Derek J. Smith include Erasmus University Medical Center & Texas Instruments.
Papers
More filters
Journal ArticleDOI
Reemergence of Enterovirus 71 in 2008 in Taiwan: Dynamics of Genetic and Antigenic Evolution from 1998 to 2008
Sheng Wen Huang,Yun Wei Hsu,Derek J. Smith,Derek J. Smith,Derek J. Smith,David Kiang,Huey Pin Tsai,Kuei Hsiang Lin,Shih Min Wang,Ching Chung Liu,Ih-Jen Su,Jen Ren Wang +11 more
TL;DR: In this article, the authors reported that the reemerging EV71 genotype B5 strains formed a separate cluster which was antigenically distinct from the B4 and C genotypes.
Journal ArticleDOI
Limited airborne transmission of H7N9 influenza A virus between ferrets
Mathilde Richard,Eefje J. A. Schrauwen,Miranda de Graaf,Theo M. Bestebroer,Monique I. J. Spronken,Sander van Boheemen,Dennis de Meulder,Pascal Lexmond,Martin Linster,Sander Herfst,Derek J. Smith,Judith M. A. van den Brand,David F. Burke,Thijs Kuiken,Guus F. Rimmelzwaan,Albert D. M. E. Osterhaus,Ron A. M. Fouchier +16 more
TL;DR: It is shown that although the A/Anhui/1/2013 A(H7N9) virus harbours determinants associated with human adaptation and transmissibility between mammals, its airborneTransmissibility in ferrets is limited, and it is intermediate between that of typical human and avian influenza viruses.
Journal ArticleDOI
Discordant antigenic drift of neuraminidase and hemagglutinin in H1N1 and H3N2 influenza viruses
Matthew R. Sandbulte,Kim B. Westgeest,Jin Gao,Xiyan Xu,Alexander Klimov,Colin A. Russell,David F. Burke,Derek J. Smith,Ron A. M. Fouchier,Maryna C. Eichelberger +9 more
TL;DR: A single point mutation in the NA of A/Brisbane/59/2007 was primarily responsible for the lack of inhibition by polyclonal antibodies specific for earlier strains, underscoring the importance of NA inhibition testing to define antigenic drift when there are sequence changes in NA.
Journal ArticleDOI
Dengue viruses cluster antigenically but not as discrete serotypes
Leah C. Katzelnick,Judith M. Fonville,Judith M. Fonville,Judith M. Fonville,Gregory D. Gromowski,Jose Bustos Arriaga,Angela M. Green,Sarah James,Sarah James,Louis Lau,Magelda Montoya,Chunling Wang,Laura A. VanBlargan,Colin A. Russell,Hlaing Myat Thu,Theodore C. Pierson,Philippe Buchy,John Aaskov,Jorge L. Muñoz-Jordán,Nikos Vasilakis,Robert V. Gibbons,Robert B. Tesh,Albert D. M. E. Osterhaus,Ron A. M. Fouchier,Anna P. Durbin,Cameron P. Simmons,Cameron P. Simmons,Edward C. Holmes,Eva Harris,Stephen S. Whitehead,Derek J. Smith,Derek J. Smith,Derek J. Smith +32 more
TL;DR: Dengue viruses show as much divergence within a type as between types, which helps explain why immune responses to dengue are highly variable, and it has complex implications for epidemiology, disease, and vaccine deployment.
Dynamics of Genetic and Antigenic Evolution from 1998 to 2008
Sheng-Wen Huang,Yun-Wei Hsu,Derek J. Smith,David Kiang,Huey Pin Tsai,Kuei-Hsiang Lin,Shih Min Wang,Ching-Chung Liu,Ih-Jen Su,Jen Ren Wang +9 more
TL;DR: Continuous surveillance of EV71 including the monitoring of genetic evolution and antigenic changes is recommended and may contribute to the development of a vaccine for EV71.