D
Derek J. Smith
Researcher at University of Cambridge
Publications - 135
Citations - 18468
Derek J. Smith is an academic researcher from University of Cambridge. The author has contributed to research in topics: Virus & Influenza A virus. The author has an hindex of 54, co-authored 121 publications receiving 16430 citations. Previous affiliations of Derek J. Smith include Erasmus University Medical Center & Texas Instruments.
Papers
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Journal ArticleDOI
Unifying Viral Genetics and Human Transportation Data to Predict the Global Transmission Dynamics of Human Influenza H3N2
Philippe Lemey,Andrew Rambaut,Trevor Bedford,Nuno R. Faria,Filip Bielejec,Guy Baele,Colin A. Russell,Derek J. Smith,Oliver G. Pybus,Dirk Brockmann,Marc A. Suchard +10 more
TL;DR: The integrated approach introduced here offers great potential for epidemiological surveillance through phylogeographic reconstructions and for improving predictive models of disease control by demonstrating that predictions of influenza spatial spread are most accurate when data on human mobility and viral evolution are integrated.
Journal ArticleDOI
Integrating influenza antigenic dynamics with molecular evolution
Trevor Bedford,Marc A. Suchard,Philippe Lemey,Gytis Dudas,Victoria Gregory,Alan Hay,John W. McCauley,Colin A. Russell,Derek J. Smith,Derek J. Smith,Andrew Rambaut,Andrew Rambaut +11 more
TL;DR: Previous approaches to antigenic cartography are extended, and simultaneously characterize antigenic and genetic evolution by modeling the diffusion of antigenic phenotype over a shared virus phylogeny, and it is shown that A/H3N2 evolves faster and in a more punctuated fashion than other influenza lineages.
Journal ArticleDOI
The Potential for Respiratory Droplet–Transmissible A/H5N1 Influenza Virus to Evolve in a Mammalian Host
Colin A. Russell,Colin A. Russell,Colin A. Russell,Judith M. Fonville,Judith M. Fonville,André Ex Brown,David F. Burke,David F. Burke,David L. Smith,David L. Smith,Sarah James,Sarah James,Sander Herfst,Sander van Boheemen,Martin Linster,Eefje J. A. Schrauwen,Leah C. Katzelnick,Leah C. Katzelnick,Ana Mosterin,Ana Mosterin,Ana Mosterin,Thijs Kuiken,Eileen A. Maher,Gabriele Neumann,Albert D. M. E. Osterhaus,Yoshihiro Kawaoka,Ron A. M. Fouchier,Derek J. Smith +27 more
TL;DR: A mathematical model of within-host virus evolution was used to study factors that could increase and decrease the probability of the remaining substitutions evolving after the virus has infected a mammalian host, making a virus evolving in nature a potentially serious threat.
Proceedings ArticleDOI
LetterWise: prefix-based disambiguation for mobile text input
TL;DR: A new technique to enter text using a mobile phone keypad, called LetterWise, takes significantly less memory and allows entry of non-dictionary words without switching to a special input mode.
Journal ArticleDOI
Enhancing disease surveillance with novel data streams: challenges and opportunities
Benjamin M. Althouse,Samuel V. Scarpino,Lauren Ancel Meyers,Lauren Ancel Meyers,John W. Ayers,Marisa Bargsten,Joan Baumbach,John S. Brownstein,John S. Brownstein,John S. Brownstein,Lauren Castro,Hannah E. Clapham,Derek A. T. Cummings,Sara Y. Del Valle,Stephen Eubank,Geoffrey Fairchild,Lyn Finelli,Nicholas Generous,Dylan B. George,David R. Harper,Laurent Hébert-Dufresne,Michael A. Johansson,Kevin J. Konty,Marc Lipsitch,Gabriel J. Milinovich,Joseph D. Miller,Elaine O. Nsoesie,Elaine O. Nsoesie,Donald R. Olson,Michael J. Paul,Philip M. Polgreen,Reid Priedhorsky,Jonathan M. Read,Isabel Rodriguez-Barraquer,Derek J. Smith,Christian Stefansen,David L. Swerdlow,Deborah L. Thompson,Alessandro Vespignani,Amy Wesolowski +39 more
TL;DR: This paper outlines a conceptual framework for integrating NDS into current public health surveillance and presents the case that clearly articulating surveillance objectives and systematically evaluating NDS and comparing the performance of NDS to existing surveillance data and alternative NDS data is critical.