D
Derek J. Smith
Researcher at University of Cambridge
Publications - 135
Citations - 18468
Derek J. Smith is an academic researcher from University of Cambridge. The author has contributed to research in topics: Virus & Influenza A virus. The author has an hindex of 54, co-authored 121 publications receiving 16430 citations. Previous affiliations of Derek J. Smith include Erasmus University Medical Center & Texas Instruments.
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Apparatus, systems and methods for distributed signal processing
TL;DR: In this paper, an active memory 14 is provided which includes a data memory 20 including rows and columns of storage locations for holding data and computational results, and a broadcast memory 22 includes rows and column of storage location for holding control instructions.
Journal ArticleDOI
Full restoration of viral fitness by multiple compensatory co-mutations in the nucleoprotein of influenza A virus cytotoxic T-lymphocyte escape mutants.
Guus F. Rimmelzwaan,Eufemia Berkhoff,Nella J. Nieuwkoop,Derek J. Smith,Ron A. M. Fouchier,Albert D. M. E. Osterhaus +5 more
TL;DR: The nucleoprotein displays unexpected flexibility to overcome functional constraints imposed by CTL epitope sequences, allowing influenza viruses to escape from specific CTLs and improve viral fitness of viruses containing 375G and 384R.
Journal ArticleDOI
H7 avian influenza virus vaccines protect chickens against challenge with antigenically diverse isolates.
Muhammad Athar Abbas,Erica Spackman,Ron A. M. Fouchier,Derek J. Smith,Derek J. Smith,Derek J. Smith,Zaheer Ahmed,Naila Siddique,Luciana Sarmento,Khalid Naeem,Enid T. McKinley,Abdul Hameed,Shafqat Fatima Rehmani,David E. Swayne +13 more
TL;DR: All vaccines provided similar protection against mortality, morbidity and shedding of challenge virus from the respiratory tract, however, some minor (not statistically significant) differences were observed and correlated with antibody levels induced by the vaccine prior to challenge.
Journal ArticleDOI
A review of Influenza haemagglutinin receptor binding as it relates to pandemic properties
TL;DR: Current evidence suggests that mortality associated with any emergent pandemic from current strains may be reduced if haemagglutinin specificity changes, further emphasising the importance of understanding how and if selection pressures in the human will cause such an alteration.
Posted ContentDOI
Mapping SARS-CoV-2 antigenic relationships and serological responses
S. H. Wilks,Barbara Mühlemann,Xiaoying Shen,Sina Türeli,Eric B. LeGresley,Antonia Netzl,Miguela A. Caniza,Jesus N Chacaltana-Huarcaya,Victor M. Corman,Xiaoju Daniell,Michael B. Datto,Fatimah S. Dawood,Thomas N. Denny,Christian Drosten,Ron A. M. Fouchier,Patricia García,Peter Halfmann,Agatha N. Jassem,Lara Maria Jeworowski,Terry Jones,Yoshihiro Kawaoka,Florian Krammer,Charlene McDanal,Rolando Pajon,Viviana Simon,Melissa S. Stockwell,Haili Tang,Harm van Bakel,Vic Veguilla,Richard J. Webby,David C. Montefiori,Derek J. Smith +31 more
TL;DR: Antigenic cartography of SARS-CoV-2 variants reveals amino acid substitutions governing immune escape and immunodominance patterns, with implications for variant risk assessment and vaccine strain selection.